After tissue infiltration, macrophages contribute to innate immune responses through antigen presentation, the production of several cytokines, such as IL-1, IL-6, and TNF-α, and the...
Although there is a lack of strong evidence on the efficacy of cannabinoids for the treatment of RA and other rheumatic diseases, cannabinoids have been seen as a potential therapy d...
The characterization and inclusion behavior of inclusion complex of amantadine conjugated cannabinoid (AD-CBD) and biotin-ethylenediamine-β-cyclodextrin (BIO-CD) in solution and soli...
Although it has been shown that CBD has anti-cancer effects on cancer cells, not much is known about the effect of CBD on cancer stem cells. Here, we show that CBD reduced viability ...
The results in the THC-dominant group in the present study are similar to findings from our prior study18, in which individuals using 70% or 90% THC concentrate products demonstrated...
Similarly, no statistically significant result was found regarding the strength of CBD used, suggesting that there is not a dose-dependent relationship with N-back performance. Salie...
Although THC is a weak partial agonist of CBand CB, as far as the stress response is concerned, THC appears to act as a competitive inhibitor of AEA and 2-AG at CB, and THC increases...
This copolymer is named CS-PMMA30, where 30 represents the relative PMMA weight content in the copolymer (%PMMA), as determined by proton-nuclear magnetic resonance (1H-NMR, see belo...
Two major cannabinoids of cannabis, namely cannabidiol (CBD) and tetrahydrocannabinol (THC) have been reportedly used as alternative medicine for diabetes treatment in both pre-clini...
The aim of this study was to assess the personal experience and attitudes of Slovenian pet owners regarding cannabinoid (CBD) use and to identify the predictors of the first use and ...
Given the inhibitory effects of THC:CBD on TLR3 signalling to CXCL10 and IFN-β in PBMCs, in addition to evidence linking TLR4 to MS pathogenesis [ 15 16 ], we next set out to determi...
The uniqueness of CIK cells is their encouraging synergetic effect with cancer associated inhibitors/compounds in preclinical models since cannabinoids have been the subject of inten...
The aim of this study was two-fold: (1) determine whether CBD/CBDA rich hemp extract can help control canine refractory epileptic seizure patients who are only partially responsive t...
In the veterinary medicine, therapeutic applications of CBD in dogs include osteoarthritis-associated pain (6, 25, 26), aggressive behavior (27), and epilepsy (7, 28). We hypothesize...
with high THC content is cultivated for medical applications and/or recreational use [ Cannabis plants are easy to cultivate, as they do not require a specific type of soil; however,...
No effect on type I collagen protein expression was observed in cells cultured with A549 cell CM without TGFβ treatment ( Figure 6 B,F). We cultured A549 cells with NF or CAF CM trea...
The results showed that CBD administration did not influence motor activity evaluated by accelerating rotarod tests, while it reduced locomotor activity in the OF [ 42 ]. In summary,...
Breast cancer is the most common malignancy in women worldwide. The aim of this study was to investigate the effect of cannabidiol on estrogen receptor-positive and estrogen receptor...
Based on prior research, we hypothesize that fertility treatments would not significantly change cannabinoid ratio, and that higher N fertility regimes would increase biomass yield. ...
Table 1 Summary of laboratory tests throughout the experimental treatment and follow-up Full size table AD history The patient was diagnosed with AD 2 years prior to the start of t...
The thermic effect of food was examined using two-way ANOVA with repeated measures comparing energy expenditure across time for the two conditions (i.e., CBD and placebo); respirator...
In the most prevalent proposed use, cancer, CBD was proposed for curative or primary treatment (n=57), pain/symptom relief from cancer and cancer treatment (n=24), enhancing conventi...
Irrespective of the study design, three studies reported that CBD alleviated psychotic symptoms and cognitive impairment in patients with chronic cannabis use and Parkinson’s disease...
The results indicate that there is a significant effect of increasing concentrations of THC and CBD on blood viscosity. Increased production of ROS can have a profound impact on the ...
This seeming contradiction may at least partially be due to other confounding factors within the context of metabolic disorders such as inflammation which can influence the microbiom...
Most participants did not believe it had dangerous side effects, were not aware that it is available on the UK high street and were keen for it to be prescription only. And free text...
The sample was predominantly male (70%), with a median age of 36 (interquartile range 28–44) years (Table 1). Table 1 Sociodemographic and behavioral characteristics of cannabidiol u...
This study found that the patients had an increase in overall quality of life, including improved sleep and decreased self-perceived anxiety levels and reduced pain scores. Most peop...
Transgenic animal models do not express all the factors present in the human disease, including pathological changes and disease progression; they also do not reflect the etiology of...
In addition, given that α-glucosidase inhibitors including CBD would have to survive gastrointestinal tract digestion to exert their desired inhibitory effects on α-glucosidase, the ...
Angiogenesis and endothelial dysfunction in COVID-19 Recently, upon our review research on the role of angiogenesis and endothelial dysfunction in COVID-19 (Norooznezhad and Mansour...
Study Design Participants completed two treatment sessions involving the oral administration of CBD (300 mg) or a placebo in a randomised, double-blind, crossover design. Each sessi...
CBD causes sex-dependent effects on contextual fear memory and extinction but citalopram does not affect either memory We previously found that CBD enhances contextual memory and it...
The main improvements of the treatment were as follows: a decrease in behavioral problems was reported in 10 patients (32.2%), an increase in expressive language was reported in 7 pa...
This retrospective study explored the use of CBD-rich products in a medical cannabis clinical setting in Canada and associated effectiveness on a common symptom cluster presentation ...
A follow-up study demonstrated that this mechanism of HU-331 also works against the other human isoform of topoisomerase II, TOP2B (Wilson et al. 2018). These results indicate that H...
Our group settled six formulations combining CBD and terpenes purified from Cannabis sativa L, Origanum vulgare , and Thymus mastichina . CBD is a partial agonist for ...
Many clinically effective anticonvulsants inhibit Na V channels, and purified CBD non-selectively inhibits these channels (Ghovanloo et al. 2018). Our study shows that a CBD-dominant...
Speaking to Christian Carlsen, Business Director of NNE and Morten Allesoe, Principal Consultant at NNE, Medical Cannabis Network gains an insight into the importance of achieving ca...
These receptors feed into and interact with central signalling cascades that determine the ease by which cells engage in apoptosis, and can be used as a way to prime cancer cells to ...
“If you are living in a world that is predicated on perpetual growth, and the one thing that drives this perpetual growth are these underlying environmental resources, you can’t keep...
The earliest reference to the therapeutic use of cannabis dates back to 2700 BC in ancient China, “the land of hemp and mulberry.” Cannabis (“Ma”) was subsequently included in the Pe...
The study found that CBD limited the damage caused by induced brain injury: “ CBD significantly reduces infarct volume and improved early functional outcome in experimental stroke in...
1993: CB -2 Receptor Scientists identified a second type of cannabinoid receptor – “CB2” – which is present throughout the immune system, the peripheral nervous system, metabolic ti...
When coffee and cannabis are combined, which effects win out? Adenosine: CB1 Gatekeeper A1 Adenosine Receptors CB1 cannabinoid receptors and A1 adenosine receptors both populate th...
What is CBD ? Which Is Better CBD or THC ? Begin with a small dose of high CBD/low THC oil, especially if you have little or no experience with cannabis. But single-molecule CBD is l...
The activation of a G-protein coupled receptor from a signal outside the cell releases a second messenger molecule into the cell’s interior. CB1 cannabinoid receptors – which are act...
The plant is also rich in compounds called terpenes and flavonoids, which work together with CBD and THC to create an “entourage effect” that is greater than the effect of any one of...
Several toothpaste manufacturers have taken note of research showing that CBD and other plant cannabinoids have antimicrobial properties relevant to dental care.1 Colgate has already...
“My pain kind of started to get worse in my late teens, early 20s,” recalls Carrie. I just feel better when I’m taking it.” Endometriosis & Endocannabinoid Dysfunction While ca...
What are cannabinoids? Some other states have legalized only one ingredient in Cannabis, such as cannabidiol (CBD), and these states are not included in the map. When taken by mouth,...
[22] Similarly, a study of a subset of cancer patients in the Minnesota medical Cannabis program explored changes in the severity of eight symptoms (i.e., anxiety, appetite loss, dep...
At the same time, inconsistencies in state policies conflict with federal law, which itself, scientists said at a recent NCI-sponsored Cannabis, Cannabinoids, and Cancer Research Sym...
In fact, while many patients say they experience symptom relief with cannabis products, there is no clear evidence on the benefits or potential harms, how cannabis interacts with the...
This work has not yet been published or peer-reviewed, but in a statement to Project CBD, a spokesperson said that the company has “initiated preclinical development studies to under...
Common trends in cannabis use routines First, we show the great heterogeneity of cannabis use routines for chronic pain, with some participants using a single administration route a...
A 2010 brain cancer study by California scientists found that CBD “enhances the inhibitory effects of THC on human glioblastoma cell proliferation and survival.” This means that CBD ...
A groundbreaking study from Israel has documented the superior therapeutic properties of whole plant CBD-rich cannabis extract as compared to single-molecule cannabidiol (CBD). The I...
Dose: What’s a reasonable starting dose? Tinctures & Sublingual Onset : 15 minutes to an hour. Dose: 2.5-5 mg of THC and CBD is a common starting dose. Both flower and oil can b...
12In recent years, cannabis, and cannabidiol (CBD) in particular, are once again being considered for the treatment of seizures in both humans and animals. CB 1 receptors, also part ...
Hemp plants include plants grown for fiber and plants grown for seed oil. According to current federal law, cannabis is considered hemp – not marijuana – as long as no part of the pl...
Where Does CBD Oil Come From? What does the resin do for the plant? Resinous Trichomes CBD oil is extracted from the resinous trichomes of cannabis plants. To make CBD oil, one must...
The University of Sydney-led research finds that 1500mg, the highest daily medicinal dose of cannabidiol (CBD), has no impact on people’s driving or cognitive abilities. “Our study i...
CBD does contain trace amounts of THC, but less than 0.3%, making it products legal for sale within the United States Cannabis: CBD vs. Hemp Answer the questions: Are CBD and Hemp ...
CBD is best stored in the cold, such as a refrigerator or freezer, especially in hot climates with no air conditioning. Keep Away From Air This might seem a bit funny at first, but ...
A summary of the research of CBD on… Anxiety The most commonly-reported use of recreational CBD is as a treatment for anxiety. [6] And it seems that these results are standard—a re...
Led by researchers in the Department of Orthopedic Surgery at NYU Langone Health, the study found that the tablet ORAVEXXTM safely managed pain after minimally invasive rotator cuff ...
In a study conducted by researchers at the University of São Paulo involving experiments on mice, the synthetic substance not only prevented the neuropathic pain typically induced by...
Results from a study published in the British Journal of Clinical Pharmacology may help explain why cannabidiol–a chemical component of marijuana with no psychoactive properties–redu...
Some cannabis products associated with short-term chronic pain improvements, but side effects a concern Abstract: https://www.acpjournals.org/doi/10.7326/M21- 4520 Editorial: https...
As this was the first clinical trial to assess CBD for reducing cannabis use, they tested three different doses of CBD in an adaptive design to find out which doses might be most eff...
The three-and-a-half-year project is part of the Parkinson’s Virtual Biotech, led by Parkinson’s UK, which is plugging the funding gap in drug development and fast-tracking the proje...
While CBD products are largely unregulated and unproven, companies are working to create CBD-like molecules to develop pharmaceutical therapies. Their progress is reported in Chemica...
Now a research team from University of Southern Denmark, has published a scientific study proving the effect of CBD. When we combined CBD and antibiotics, we saw a more powerful effe...
A collaborative partnership with the University of Cordoba and the University of Dundee demonstrated for the first time that cannabidiol induces the expression of heme oxygenase 1, a...
Published in Psychological Medicine, the research used fMRI scans to examine the brain activity of 13 people with a diagnosis of psychosis under the influence of a single dose of CBD...
Cannabidiol, a type of medicinal cannabis, may reduce severe behavioural problems in children and adolescents with an intellectual disability a new study has found. Associate Profess...
TLR3?is a member of the toll-like receptor family of pattern recognition receptors of the innate immune system. The researchers have two aims for their work. First, they intend to de...
CBD is short for cannabidiol, one of the compounds in the cannabinoid family which, in nature, is found only in the cannabis plant (its official scientific name is Cannabis sativa l....
Other cannabinoids include Delta-9 THC, the infamous psychoactive element in marijuana, and less popular ones like Delta-8 THC, CBN, CBG, CBDA, and CBGA. What are Cannabinoids? How M...
May be worth further exploring cannabinoids as potential cancer treatment, say researchers It may be worth exploring further the use of cannabidiol (‘CBD’) oil as a potential lung c...
Common Ways to Use CBD There are several ways to use CBD that require little to no effort. Tinctures are the most common form of taking CBD sublingually. Ways to Use CBD Every Day ...
Hershey, Pa. – Cannabidiol (CBD) oils are equally or less effective at inhibiting the growth of certain cancer cells compared to pure CBD, according to Penn State College of Medicine...
Gross was scheduled to present this research at the American Society for Pharmacology and Experimental Therapeutics annual meeting in San Diego this month. They tested the effects of...
Previous preclinical work conducted by Dr. Hurd and her lab team at Mount Sinai, in animals with a history of heroin self-administration, demonstrated that CBD reduced the animals’ t...
Their model, which takes advantage of the large, unique genetic structure of the novel coronavirus, produced classic symptoms of ARDS like the overwhelming, destructive immune respon...
What is Carrier Oil & What Does it Do? A carrier oil is an oil that is made from plants, including coconut, hemp, macadamia nut, and others. Since this oil has very little to no ...
This study adds to a growing body of evidence demonstrating the safety of cannabis and that cannabinoids might safely activate opioid’s antinociceptive effects without stimulating it...
Researchers at Western University have shown for the first time the molecular mechanisms at work that cause cannabidiol, or CBD, to block the psychiatric side-effects caused by tetra...
The method for detecting CBD and THC used to be relatively complex. These can then be analysed to determine which substance and how much of this substance they contain. The study tes...
Research from King’s College London has found that a single dose of the cannabis extract cannabidiol can help reduce brain function abnormalities seen in people with psychosis. The r...
A key mechanism weaponized by cancer cells to evade chemotherapeutic treatments in patients with multidrug-resistant cancer is the overexpression of P-glycoprotein (P-gp) on their ce...
Many currently available products also contain a mixture of THC and CBD. The research involved people inhaling vaporised cannabis containing different mixes of THC and CBD, then goin...
“This means people could potentially use lower doses of opioids and still get relief from pain. Taking less pain medication could also lead to a lowered risk of addiction or physical...
What should consumers look for in CBD oil and other CBD products? CBD from marijuana or hemp with more than 0.3% THC is still considered illegal federally, but legal in states where ...
The expression of THCAS in these hosts was very low, although it opened the door to the possibility of biotechnological Δ-THCA production by means of biotechnological platforms.was i...
1 Rs and eCBs is also suggested to be present in the heart ([ 1 Rs (the presence of which was confirmed by immunohistochemistry) by WIN55212-2 and 2-AG increased CF and decreased car...
Endocannabinoids that are produced excessively in sepsis are potential factors leading to immune dysfunction, because they suppress immune cell function by binding to G-protein-coupl...
The RPMI 1788 cell line, used as normal cells, was treated with BCP at concentrations of 50 and 100 μM for 24 h, thus demonstrating that BCP did not affect the proliferation of norma...
In addition to interacting with cannabinoid receptors 1 and 2 (CB1 and CB2, respectively), the endogenous cannabinoid system (ECS) communicates with other receptor families such as o...
The RPMI 1788 cell line, used as normal cells, was treated with BCP at concentrations of 50 and 100 μM for 24 h, thus demonstrating that BCP did not affect the proliferation of norma...
Figure 2 Structural and dynamical differences between wildtype and mutant CB1 for each activation state. (A) For each activation state, all residues are colored as blue according to ...
This receptor was identified and cloned from HL60 cells [ 3 ] and was initially considered as ‘peripheral cannabinoid receptor’ due to its wide distribution in peripheral cells and t...
CBG seems to be a potent TRPM8 antagonist (IC50 = 0.16 ± 0.02), which suggests it may have a therapeutic effect in these types of cancers [ 72 ]. From this class of phytocannabinoids...
On the other hand, the intraplantar injection of the CB 2 cannabinoid receptor antagonist AM630 (100 μg/paw) did not significantly reduce the antinociceptive effect of kahweol (80 μg...
In addition, after administration of different doses of ethanol, a marked increase of tyrosine hydroxylase (TH) gene expression in the VTA and MOr in the NAcc was observed. In contra...
The RPMI 1788 cell line, used as normal cells, was treated with BCP at concentrations of 50 and 100 μM for 24 h, thus demonstrating that BCP did not affect the proliferation of norma...
Nowadays cardiovascular diseases (CVDs) are the major causes for the reduction of the quality of life. The endocannabinoid system is an attractive therapeutic target for the treatmen...
Concentration values in healthy, normal-weight females (F,= 76) and males (M,= 45) ranged in the following intervals: AEA, 0.40–1.65 pmol/mL (F) and 0.41–1.88 pmol/mL (M); 2-AG, 0.69...
As described for the endocannabinoids, the overall pharmacological action of the minor cannabinoids often results from binding at both cannabinoid and “off target” receptors. Althoug...
Introduction i /G o protein) [ The G-protein-coupled receptors (GPCRs), containing about 800 members, are the largest membrane protein family known in the human body [ 1 ]. Although...
ARDS was induced in mice as described previously [ 9 28 ]. To that end, we measured the levels of SCFAs in Naïve, SEB + VEH and SEB + AEA and we found that butyric acid, valeric acid...
Thus, epilepsy syndromes include not only seizures, but also several comorbid conditions related to behavioral and psychiatric disorders such as cognitive impairments, depression, an...
This process is impaired during later stages of AD and the increased levels of tau lead to enhanced activation of microglia [ 59 ]. However, most of the studies investigate the overa...
Cancer, as a mysterious and complex disease, has a multi-stage molecular process that uses the cellular molecular machine and multiple signaling pathways to its advantage. Cannabinoi...
Indeed, several studies have revealed the health risks of using these devices, as well as traditional cigarettes and any other tobacco product [ 26 29 ]. On the contrary, more recent...
The CBR2 is mainly found on the surfaces of immune cell types, though its expression has also been observed in the CNS [ 31 ]. THC, CBD, and R(+)-methanandamide have been shown to st...
With hemp balm, the content of CBDA amounted to 44.7–80.4 mg/g of the product, CBD amounted to 7.6–13.8 mg/g, while CBGA and CBG were present in considerably lower concentrations, 2....
Summary of cognitive deficits induced by chemotherapeutic drugs in preclinical animal models of chemotherapy-induced cognitive impairment (CICI). Several studies have observed that t...
Plasmids contain genes to express resistance to antibiotics. When a biofilm forms, bacterial cells acquire 10–1000 times more resistance to antibiotics [ 46 ]. The oral administratio...
The cannabinoid receptor 2 (CB2 receptor) has attracted considerable interest, mainly due to its potential as a target for therapeutics for treating various diseases that have a neur...
Two major cannabinoids of cannabis, namely cannabidiol (CBD) and tetrahydrocannabinol (THC) have been reportedly used as alternative medicine for diabetes treatment in both pre-clini...
19,35,78,83,200,14,87,107,117,156,167,169,26,44,46,71,72, A formidable challenge is gauging the intake of cannabinoids, as the dosages and potency of different cannabinoid preparatio...
Results: Many studies have demonstrated that endocannabinoids (eCBs) and cannabinoid receptors (CBRs) are expressed in bone and synovial tissues, playing important roles in bone meta...
2-AG activates both CB1R and CB2R. Pain 162, S1–S2. Pain 154, 160–174. Activation of dorsal horn cannabinoid CB2R receptor suppresses the expression of P2Y12 and P2Y13 receptors in n...
We found that the CB2Ra transcript levels are about 8-fold higher than that of CB2Rb in human islets (Figure 2B), indicating that the upstream promoter is more active in cell types o...
Indeed, the densities of eCB receptors and the levels of eCBs have been suggested as possible biomarkers in neuropsychiatric disorders [ 75 ]. A study to evaluate the expression of C...
(c) CB2 protein expression in HEK293 with or without transfected CB2R, using GAPDH as loading control. (c) CB2 protein expression in HEK293 with or without transfected CB2R, using GA...
Transdermal Delivery of Cannabinoids and Challenges All advantages mentioned above of transdermal drug delivery over other formulations and considering dermatologists are interested...
Many of the CB 2 receptors were expressed in activated M1 microglia, although astrocytes were also identified as CB 2 receptor positive. As aged brains exhibit a highe...
The ligands AEA and 2-AG, belonging to the N-acylethanolamine (NAE) and monoacylglycerol (MAG) families, respectively, were classified as cannabinoids and gained a significant amount...
Regarding previous works, the results of size and ZP of the plain PLGA NPs and THC-PLGA NPs here presented correlate with them11,17,18,19. The similar values of size and ZP of plain ...
Certainty of Evidence for Medical Marijuana Effects on MS Symptom Outcomes This systematic review of the literature evaluated the evidence for benefits of medical marijuana treatmen...
We used two indicators to analyze the movement of this part (Figure 2B): 1) the distance between Y2945.58 and Y3977.53, the two conserved residues in class A GPCRs that lay far apart...
All treatments did not affect spheroid size at 70 h. During the formation of 3D aggregates, the size and shape of spheroids have been shown to be primarily determined by cell–cell an...
Involvement of CB 1 and CB 2 Receptors It has also been reported that, as with DGLα, expression of the CB 1 receptor is affected by epileptogenesis (Figure 2). Taken together, these...
Almost 4% of the global population aged between 15 and 64 years used cannabis at least once in the last year, according to the 2021 World Drug Report [ 1 ]. Outside of teens, older a...
The cells are then sent to a settling tank (ST-101) in which ethyl acetate is used with a 2:1 ratio to resuspend the cells and subsequently promote liquid-liquid extraction. The biph...
Superior analgesic effects compared with placebo were demonstrated in randomized clinical trials (RCTs)15–19 and in a large observational study.20 A recent meta-analysis of nine RCTs...
The number of participants (patients included) shows great variability among the analyzed studies. Another study [ 61 ] (p. 1286) published in 2018 evaluated that 60 children with au...
There is evidence that also other non-CB1R and non-CB2R (GPR18, GPR119, and GPR55) are involved in the signaling of the ECS [18]. AEA and 2-AG can also activate other receptors, such...
60 Cannabinoids have been shown to have varying effects on the ability of tumors to establish a metastasis, although from much of the data it is unclear at which stage of metastasis ...
The following supporting information can be downloaded at: https://www.mdpi.com/article/10.3390/cells11040723/s1 , Figure S1: Cell viability analysis of CBD on HIV-1 infected monocyt...
Low‐quality evidence from both RCTs and NRSIs shows no significant benefits of cannabinoids for weight gain, appetite stimulation, and better quality of life, three important outcome...
The measurements were done on five plants per breeding population (N = 5). Photosynthetic Parameters Most photosynthetic parameters differed significantly between breeding populatio...
When dissociated spleen cells were placed in culture ex vivo and stimulated with C3HeB/FeJ cells in an MLR, the cells from the O-1966 treated mice were significantly suppressed in th...
Cannabinoid type 2 receptor signaling. The involvement of CB2Rs in ALS has been demonstrated by different studies. Brain cannabinoid CB2 receptors modulate cocaine’s actions in mice....
In the prediction of total THC content, RPD values > 2 were obtained, which indicates the goodness of the models. The best model to predict CBD content was also obtained without a...
The hemp plant consists of the woody part (44% of the plant weight), fibres (24%), seeds (11%) and other components such as flowers, leaves and dust (21%) [ 1 3 ]. Since each part of...
As medicinal cannabis related clinical research has predominately focused on CNS-related diseases, such as neurodegeneration and neurological disorders, pain, substance use disorders...
Other efforts to study the effect of cannabinoids and the endocannabinoid system on cancer progression have included analyses of cannabinoid receptor expression levels in cancer tiss...
Common hemp seed food products include bulk or packaged raw hulled hemp seeds, hemp seed oil, hemp protein “concentrates” or powders, and hemp milk, among others. Goog...
In recent years, cannabinoid (CB) products have gained popularity among the public. The anti-inflammatory properties of CBs have piqued the interest of researchers and clinicians bec...
In C. sativa, cannabinoids are biosynthesized as phytoprotectants: in fresh biomass, 95% of the THC, CBD, and CBC exist as their acidic parents: tetrahydrocannabinolic acid (THCA), c...
Ultimately, 25 studies (Ahmed et al. 2015; Balash et al. 2017; Bruce et al. 2018; Carroll et al. 2004; Chagas et al. 2014a; Chagas et al. 2014b; Consroe et al. 1991; Curtis et al. 20...
Regarding polymorphism in general, it can be seen in Fig. This search was conducted not only on the large number of publications captured under “cannabinoids” in general but also the...
One analysis provided a breakdown of this collective funding by country, finding that more than $1.4 billion funded researchers in the USA; the UK at $39.9 million, and Canada at $36...
In probing astrocytes to understand the biological effects of cannabis, the researchers take a novel approach as earlier studies have focused primarily on neurons.” “One might imagi...
Getting to this point has meant developing a new manufacturing process that overcomes many of the challenges associated with plant-based extraction, a cornerstone of large-scale cann...
The team’s research focused specifically on the role of cannabinoid acids – CBD-A, CBG-A, and THC-A. You’ve been studying hemp for years. Think of the mass spectrometer as the magnet...
And then we found about 31 biomarkers in our group of patients and we measured their biomarkers for autism that actually showed some relevance to the autism and to the cannabis treat...
It gets even more complicated when we consider that the effects of cannabis are mediated primarily by the endocannabinoid system, which scientists believe interacts with all biologic...
Dopamine, cannabinoid, and adenosine receptors signal together to coordinate attention and impulsivity. But the increased impulsiveness induced by WIN in this rat experiment was prev...
For example, scientists recently found that topical cannabinoid-based preparations can be effective against MRSI, the deadly antibiotic-resistant flesh-eating disease. The cannabinoi...
The human body possesses specific binding sites (“locks”) on the surface of many cell types, and our body produces several endocannabinoids (“keys”) that bind to these cannabinoid re...
We will introduce the two major receptors, focusing on the CB 1 receptors due to their high expression levels in the CNS; their endogenous ligands or endocannabinoids ...
In 2014, section 7606 of the U.S. Congress Agricultural Act of 2014, the “Farm Bill”, authorized pilot programs on cultivation of industrial hemp, defined as “the plant Cannabis sati...
Treatments of the first experiment of male flowers induction on female plants of Cannabis sativa. Number of male flowers per plant and number of germinated pollen cells in vitro afte...
Considering the GC-MS results, the following concentrations of nonintoxicating phytocannabinoids and caryophyllane sesquiterpenes, in 50 μg/mL of FOJ and FOS, respectively, were test...
The effects of UV-PFD (μmol⋅m–2⋅s–1) applied during the flowering stage on aboveground tissue moisture content (%), stem dry weight (DW; g⋅m–2), and cannabinoid and terpene concentra...
Fertilized flowers are considerably less potent, likely due to changes in the contents of phytocannabinoids and terpenoids; therefore, this study examined the effect of fertilization...
Plasmids contain genes to express resistance to antibiotics. When a biofilm forms, bacterial cells acquire 10–1000 times more resistance to antibiotics [ 46 ]. The oral administratio...
The legal Cannabis industry heavily markets products to consumers based on widely used labeling systems purported to predict the effects of different “strains.” We analyzed the canna...
To find relevant articles, we searched the following search on ISI Web of Science database on February 2, 2021: “Cannabis yield photoperiod,” “Cannabis lighting,” “Can...
In both references, topping generated a higher number of side shoots, thus more top terminal inflorescence biomass than the control plants (not pruned). The significantly higher biom...
The aim of this study was to assess the personal experience and attitudes of Slovenian pet owners regarding cannabinoid (CBD) use and to identify the predictors of the first use and ...
Studies confirming these or other molecular anti-cancer effects of cannabinoids in pediatric cancer cells are scarce, and given the differences between pediatric and adult tumors and...
The measurements were done on five plants per breeding population (N = 5). Photosynthetic Parameters Most photosynthetic parameters differed significantly between breeding populatio...
A total of 2 different extraction procedures were performed according to previous published studies [ 30 32 ] to obtain medical Cannabis oil 1 (MCO-1) and MCO-2 (SIFAP and Calvi meth...
The applications of plants as medicines predates human history. One notable medicinal plant that has continued to garner attention over the years, and in recent times, is Cannabis s...
Usage sessions included real-time subjective changes in fatigue intensity levels prior to and following Cannabis consumption, Cannabis flower characteristics (labeled phenotype, cann...
Cannabis sativa is a quantitative short-day plant where decreasing daylength (often) regulates flowering initiation (van der Werf et al., 1994). Some studies reported that shorter ph...
The legalization of cannabis in many countries, as well as the decrease in perceived risks of cannabis, have contributed to the increase in cannabis use medicinally and recreationall...
Cannabinoids are the active medicinal constituents against the development of numerous conditions. Then these naturally cannebinoids acids are converted via decarboxylation, which re...
Cannabis sativa L. has a wide range of therapeutic applications against several diseases, and many review articles have detailed its chemistry [ C. sativa L. in addition to Δ9-THC in...
Most patient access, however, is through the Special Access Scheme Category B (SAS-B) which allows practitioners to make an application to the TGA to allow an individual patient to b...
Plants of Cannabis sativa KKU05 grown under different conditions: T1, control without AMF inoculum; T2, Non-mycorrhizal plants with synthetic NPK fertilizer; T3, Plants inoculated wi...
Common hemp seed food products include bulk or packaged raw hulled hemp seeds, hemp seed oil, hemp protein “concentrates” or powders, and hemp milk, among others. Goog...
Materials and Methods Basic Parameters of the Growing Space Cannabis plants were grown on tables in a room with controlled conditions. Plant density was 27.5 plants per m2 (55 plan...
Cannabis sativa L. is an intriguing plant that has been exploited since ancient times for recreational, medical, textile and food purposes. The plant’s most promising bioactive const...
Results The review highlights dental concerns of cannabis usage, the need to understand the endocannabinoid system (ECS), cannabinoid receptor system, its endogenous ligands, pharmac...
As for plant patents, 30 cannabis plant patents and applications have been filed in the USA. For more information on the PatSnap software operations, see the “Materials and methods” ...
The SCRA + cannabis group were largely male, although somewhat older [Mdn (IQR) = 32(17)] than those described in earlier research (Winstock and Barratt 2013b; Barratt et al. 2013). ...
It is also believed that curing can increase cannabis potency as the number of cannabinoids such as THC and CBN will increase by curing. The use of ethanol for maceration extraction ...
This study shows that over half of the webpages containing information about medical cannabis are from news websites, which indicates the newsworthiness of this topic. Therefore, the...
The findings of this study could be compared with the results from the few previous studies of MC in patients with FMS. One strength of the current study was evaluation of the effect...
The Internet is a frequent source for information, including for those seeking information on the medical use of cannabis (Kruger et al. 2020b). The current study found that informat...
One analysis provided a breakdown of this collective funding by country, finding that more than $1.4 billion funded researchers in the USA; the UK at $39.9 million, and Canada at $36...
At the same time, SCD allows us to detect compounds that contain sulfur very easily. Indeed, as we analyzed many datasets, we found that the compounds present in the SCD data and the...
Specifically, in this research we acquired hyperspectral images from freshly harvested leaf and flower materials of five cultivars of CBD hemp at five growth stages using a benchtop ...
Bod Australia is to start a clinical trial of its medicinal cannabis product, MediCabilis 5%, to treat long Covid-19 after the UK Medicines and Healthcare Products Regulatory Agency ...
The results in the THC-dominant group in the present study are similar to findings from our prior study18, in which individuals using 70% or 90% THC concentrate products demonstrated...
Two major cannabinoids of cannabis, namely cannabidiol (CBD) and tetrahydrocannabinol (THC) have been reportedly used as alternative medicine for diabetes treatment in both pre-clini...
The total duration of the study was 30 h from administration of the study preparation to the last blood sample taken. Assessments Plasma samples were collected on Study day 1 pre-do...
Superior analgesic effects compared with placebo were demonstrated in randomized clinical trials (RCTs)15–19 and in a large observational study.20 A recent meta-analysis of nine RCTs...
Given the inhibitory effects of THC:CBD on TLR3 signalling to CXCL10 and IFN-β in PBMCs, in addition to evidence linking TLR4 to MS pathogenesis [ 15 16 ], we next set out to determi...
No effect on type I collagen protein expression was observed in cells cultured with A549 cell CM without TGFβ treatment ( Figure 6 B,F). We cultured A549 cells with NF or CAF CM trea...
Based on prior research, we hypothesize that fertility treatments would not significantly change cannabinoid ratio, and that higher N fertility regimes would increase biomass yield. ...
Table 1 Summary of laboratory tests throughout the experimental treatment and follow-up Full size table AD history The patient was diagnosed with AD 2 years prior to the start of t...
The results indicate that there is a significant effect of increasing concentrations of THC and CBD on blood viscosity. Increased production of ROS can have a profound impact on the ...
This seeming contradiction may at least partially be due to other confounding factors within the context of metabolic disorders such as inflammation which can influence the microbiom...
(b) Sensors developed for THC detection in oral fluids samples Fig. The detection limits have been indicted to be 0.5 μM THC and 0.2 mM alcohol. Taken from (Mishra et al. 2020) with...
Most participants (83%) also reported consuming delta-9-THC cannabis and products and reported substitution for delta-9-THC (57%) and pharmaceutical drugs (59%). Participants’ respon...
Speaking to Christian Carlsen, Business Director of NNE and Morten Allesoe, Principal Consultant at NNE, Medical Cannabis Network gains an insight into the importance of achieving ca...
The earliest reference to the therapeutic use of cannabis dates back to 2700 BC in ancient China, “the land of hemp and mulberry.” Cannabis (“Ma”) was subsequently included in the Pe...
1993: CB -2 Receptor Scientists identified a second type of cannabinoid receptor – “CB2” – which is present throughout the immune system, the peripheral nervous system, metabolic ti...
Much work still needs to be done to establish that cannabis and cannabinoids can fight cancer in humans, including as an adjunct to other therapies like chemo and radiation, and to i...
When coffee and cannabis are combined, which effects win out? Adenosine: CB1 Gatekeeper A1 Adenosine Receptors CB1 cannabinoid receptors and A1 adenosine receptors both populate th...
What is CBD ? Which Is Better CBD or THC ? Begin with a small dose of high CBD/low THC oil, especially if you have little or no experience with cannabis. But single-molecule CBD is l...
The activation of a G-protein coupled receptor from a signal outside the cell releases a second messenger molecule into the cell’s interior. CB1 cannabinoid receptors – which are act...
The plant is also rich in compounds called terpenes and flavonoids, which work together with CBD and THC to create an “entourage effect” that is greater than the effect of any one of...
What are cannabinoids? Some other states have legalized only one ingredient in Cannabis, such as cannabidiol (CBD), and these states are not included in the map. When taken by mouth,...
[22] Similarly, a study of a subset of cancer patients in the Minnesota medical Cannabis program explored changes in the severity of eight symptoms (i.e., anxiety, appetite loss, dep...
In fact, while many patients say they experience symptom relief with cannabis products, there is no clear evidence on the benefits or potential harms, how cannabis interacts with the...
This work has not yet been published or peer-reviewed, but in a statement to Project CBD, a spokesperson said that the company has “initiated preclinical development studies to under...
Common trends in cannabis use routines First, we show the great heterogeneity of cannabis use routines for chronic pain, with some participants using a single administration route a...
Dose: What’s a reasonable starting dose? Tinctures & Sublingual Onset : 15 minutes to an hour. Dose: 2.5-5 mg of THC and CBD is a common starting dose. Both flower and oil can b...
Hemp plants include plants grown for fiber and plants grown for seed oil. According to current federal law, cannabis is considered hemp – not marijuana – as long as no part of the pl...
What is Delta-8 THC? Delta-8-Tetrahydrocannabinol (Delta-8 for short) is a legal cannabinoid that can give you a heady high while only containing 0.3% THC, the same as CBD. Unfortuna...
Other cannabinoids include Delta-9 THC, the infamous psychoactive element in marijuana, and less popular ones like Delta-8 THC, CBN, CBG, CBDA, and CBGA. What are Cannabinoids? How M...
This study adds to a growing body of evidence demonstrating the safety of cannabis and that cannabinoids might safely activate opioid’s antinociceptive effects without stimulating it...
Researchers at Western University have shown for the first time the molecular mechanisms at work that cause cannabidiol, or CBD, to block the psychiatric side-effects caused by tetra...
A key mechanism weaponized by cancer cells to evade chemotherapeutic treatments in patients with multidrug-resistant cancer is the overexpression of P-glycoprotein (P-gp) on their ce...
“This means people could potentially use lower doses of opioids and still get relief from pain. Taking less pain medication could also lead to a lowered risk of addiction or physical...
Increased expression of the components of the ECS and elevated levels of endocannabinoids increase food intake and produce hunger due to the activation of orexigen pathways in the hy...
It involves a combination of cannabinoid receptors, endogenous cannabinoids (endocannabinoids), and enzymes responsible for the synthesis and degradation of endocannabinoids. The fir...
There is a definite need for more RCT studies, especially in severe mood disorders such as MDD and BD, where there is a lack of such studies. CBD-enriched preparations appear to show...
In addition, recent studies have shown that the induction of autophagy is associated with these apoptotic effects and is involved in the toxicity of cannabinoid compounds to cancer c...
This indicates that an increase in AEA during exercise might be one of the factors involved in the exercise-induced increase in peripheral BDNF levels and that AEA high levels during...
Editorial on the Research Topic The Endocannabinoid System: Filling the Translational Gap Between Neuroscience and Psychiatry Translational research has become a priority in every ...
The inflammatory response is one of the major features of brain damage in the case of secondary injury. The anti-inflammatory effects of LXs and ATLs in TBI appear to be via binding ...
The structural stability and chemical reactivity properties of the semi-rigid NMP compounds are calculated by using Density Functional Theory (DFT). Finally, molecular docking calcul...
Although, some results suggest that certain effects of cannabinoids are not regulated by CB1 or CB2 (Brown, 2007), which has generated some debate regarding the potential existence o...
Indeed, several studies have revealed the health risks of using these devices, as well as traditional cigarettes and any other tobacco product [ 26 29 ]. On the contrary, more recent...
These results demonstrate that GSE supplementation inhibits trigeminal pain signaling in an injury-free model of migraine-like pain via activation of endocannabinoid receptors and re...
These data showed how derivate JZL195 determines antinociceptive effects through CB 1 receptors [1 (30 mg/kg), a selective FAAH inhibitor URB597 (IC 50 r FAAH = 33 nM) (reported in 1...
Results: Many studies have demonstrated that endocannabinoids (eCBs) and cannabinoid receptors (CBRs) are expressed in bone and synovial tissues, playing important roles in bone meta...
Having collected a set of multivariate data, the first step was to test the effects of the AP treatment and disease status by LME models based on 2-AG, AEA, LEA, OEA, PEA, and their ...
Many of the CB 2 receptors were expressed in activated M1 microglia, although astrocytes were also identified as CB 2 receptor positive. As aged brains exhibit a highe...
Involvement of CB 1 and CB 2 Receptors It has also been reported that, as with DGLα, expression of the CB 1 receptor is affected by epileptogenesis (Figure 2). Taken together, these...
There is evidence that also other non-CB1R and non-CB2R (GPR18, GPR119, and GPR55) are involved in the signaling of the ECS [18]. AEA and 2-AG can also activate other receptors, such...
Blood coagulation disorders or coagulopathies are a group of disorders in which there is a hypercoagulative state leading to excessive abnormal blood clot formation and tissue ischem...
Neuroprotective properties have been demonstrated in numerous studies of mice and rats whose Aβ-induced memory deficits were prevented by exogenous cannabinoids, while CBD administra...
AEA is rapidly degraded by fatty acid amide hydrolase (FAAH) enzyme and its levels can be modulated in the peripheral and central nervous system (CNS) by FAAH inhibito...
Cannabis for Gut Health Interactions between gut microbiota and the endocannabinoid system were first explored in 2010. What’s more, microbiome health may be modified and even impro...
At the same time, CBD has been shown to reduce the activity of B cells, activate T cells (by increasing the level of apoptosis), and induce Treg cells to inhibit the production of cy...
1993: CB -2 Receptor Scientists identified a second type of cannabinoid receptor – “CB2” – which is present throughout the immune system, the peripheral nervous system, metabolic ti...
A recent review of research on cannabinoid receptors and their influence on signaling pathways provides insights into how the endocannabinoid system boost energy, stimulates appetite...
What Is The Endocannabinoid System? More than 20 years later, in 1988, researchers identified the human body’s endocannabinoid system. Endocannabinoids are the special molecules natu...
To our knowledge, it is the first research about the effect of ACEA and its cannabinoid CB1 receptor subtypes on nuclear receptors (NR4A) in skeletal muscles, and it characterizes a ...
What are cannabinoids? 3.1.4 Medical marijuana and pregnancy Marijuana is the most widely used drug during pregnancy [43]. 5.1 Retrograde cannabinoid signaling, behavior, and neurona...
The sprayed aerial parts were evaluated based on phenolic (TPC) and flavonoids (TFC) contents, antioxidant capacity (by FRAP and DPPH assay), photosynthetic pigments including chloro...
The aim of this study was to assess the personal experience and attitudes of Slovenian pet owners regarding cannabinoid (CBD) use and to identify the predictors of the first use and ...
Blood coagulation disorders or coagulopathies are a group of disorders in which there is a hypercoagulative state leading to excessive abnormal blood clot formation and tissue ischem...
The legalization of cannabis in many countries, as well as the decrease in perceived risks of cannabis, have contributed to the increase in cannabis use medicinally and recreationall...
Keywords: cannabis; dermatology; new modality of treatment; anti-inflammatory; topical usage. FIGURE 1: Benefits of cannabidiol for your skin.9 Sebaceous gland related disorders Acn...
Cannabis sativa L. has a wide range of therapeutic applications against several diseases, and many review articles have detailed its chemistry [ C. sativa L. in addition to Δ9-THC in...
Cannabigerol The anti-inflammatory activity of CBG is less studied than that of CBD. Appendix A Methodology: To reflect on the effect of cannabis and its derived compounds on acute...
throughout the study. Results Recruitment and Participant Flow Among 100 pre-screened patients, 91 met inclusion criteria and were considered for study participation, however 50 pa...
Results The review highlights dental concerns of cannabis usage, the need to understand the endocannabinoid system (ECS), cannabinoid receptor system, its endogenous ligands, pharmac...
Figure 3a shows negative correlations, i.e. inverse relationships between the frequency of the reported effect and flavour tags, while Fig. C. Both positive (Panel A) and negative (P...
Abstract MicroED has recently emerged as a convenient and powerful tool for the unequivocal structure determination of small molecules and it could likely be used in cannabinoid rese...
THC and CBD are the main cannabinoids that have gained most of the attention. THCA synthase is the enzyme responsible for the production of THCA; CBDA synthase is the enzyme responsi...
At the same time, CBD has been shown to reduce the activity of B cells, activate T cells (by increasing the level of apoptosis), and induce Treg cells to inhibit the production of cy...
The sprayed aerial parts were evaluated based on phenolic (TPC) and flavonoids (TFC) contents, antioxidant capacity (by FRAP and DPPH assay), photosynthetic pigments including chloro...
The hemp plant consists of the woody part (44% of the plant weight), fibres (24%), seeds (11%) and other components such as flowers, leaves and dust (21%) [ 1 3 ]. Since each part of...
In 2022, “insomnia” and “sleep disorders” were the third and fourth most common reasons for prescription.8 Despite this increasing use of cannabis products for the treatment of sleep...
Based on prior research, we hypothesize that fertility treatments would not significantly change cannabinoid ratio, and that higher N fertility regimes would increase biomass yield. ...
The differing rates of terpene loss from inflorescence of the same chemotype, but different harvests, is further illustrative of the inherent variability of cannabis inflorescence te...
The survey showed that the majority of the sample of Colombian psychiatrists believe that MC should be available for different medical conditions and expressed a desire to be able to...
The earliest reference to the therapeutic use of cannabis dates back to 2700 BC in ancient China, “the land of hemp and mulberry.” Cannabis (“Ma”) was subsequently included in the Pe...
What are cannabinoids? Some other states have legalized only one ingredient in Cannabis, such as cannabidiol (CBD), and these states are not included in the map. When taken by mouth,...
[22] Similarly, a study of a subset of cancer patients in the Minnesota medical Cannabis program explored changes in the severity of eight symptoms (i.e., anxiety, appetite loss, dep...
At the same time, inconsistencies in state policies conflict with federal law, which itself, scientists said at a recent NCI-sponsored Cannabis, Cannabinoids, and Cancer Research Sym...
In fact, while many patients say they experience symptom relief with cannabis products, there is no clear evidence on the benefits or potential harms, how cannabis interacts with the...
Common trends in cannabis use routines First, we show the great heterogeneity of cannabis use routines for chronic pain, with some participants using a single administration route a...
The first clinical study was a small, proof-of-concept 11-subject study, where a 3%extract was found to significantly reduce sebum and erythema better than vehicle, suggesting CBD co...
In order to better characterize the effect of cannabigerol on biofilms of S. mutans , this paper provides a series of computational assays for biofilm analysis, applied on confocal i...
Early studies have shown that some cannabinoids can slow the growth of gram-positive bacteria, such as S. aureus, but not gram-negative bacteria, such as E. coli. Eric Brown, a mic...
Getting to this point has meant developing a new manufacturing process that overcomes many of the challenges associated with plant-based extraction, a cornerstone of large-scale cann...
What is the Endocannabinoid System (ECS)? As most people are already aware of THC and CBD, we’ll be covering the following lesser-known cannabinoids: CBN CBG CBC THCV What is CBN? ...
CBG, or Cannabigerol, is derived from the cannabis plant and is commonly called “the mother of all cannabinoids” or the “stem cell cannabinoid” because many other cannabinoids come f...
Other cannabinoids include Delta-9 THC, the infamous psychoactive element in marijuana, and less popular ones like Delta-8 THC, CBN, CBG, CBDA, and CBGA. What are Cannabinoids? How M...
Today, scientists are only beginning to investigate whether different cannabis compounds could be used to treat a variety of diseases. Early studies have shown that some cannabinoids...
On the other hand, the intraplantar injection of the CB 2 cannabinoid receptor antagonist AM630 (100 μg/paw) did not significantly reduce the antinociceptive effect of kahweol (80 μg...
Several endogenous peptides were discovered to activate GPR55 [ 10 ]. As depicted in Figure 3 B, the identified experiments focused on immune activation (55%), response to drug treat...
ARDS was induced in mice as described previously [ 9 28 ]. To that end, we measured the levels of SCFAs in Naïve, SEB + VEH and SEB + AEA and we found that butyric acid, valeric acid...
Recent research on the use of Cannabis in the medical field has highlighted the possible presence of an entourage effect between terpenes and cannabinoids, which could explain the ob...
Altered transcripts following THC exposure were found in a substantial number of genes linked to autism (80 genes) and intellectual disability (167 genes), with fewer overlapping wit...
Despite the millions of people infected with CHIKV and chronic arthralgia, there are no specific treatments or drugs commercially available for individuals infected with Alphaviruses...
It gets even more complicated when we consider that the effects of cannabis are mediated primarily by the endocannabinoid system, which scientists believe interacts with all biologic...
Much work still needs to be done to establish that cannabis and cannabinoids can fight cancer in humans, including as an adjunct to other therapies like chemo and radiation, and to i...
What is the Endocannabinoid System (ECS)? As most people are already aware of THC and CBD, we’ll be covering the following lesser-known cannabinoids: CBN CBG CBC THCV What is CBN? ...
Just like CBD, CBN does not produce a “high” by itself. The rats dosed with a combination of CBN and CBD were more effective at reducing pain than with using CBN alone. Unfortunately...
Other cannabinoids include Delta-9 THC, the infamous psychoactive element in marijuana, and less popular ones like Delta-8 THC, CBN, CBG, CBDA, and CBGA. What are Cannabinoids? How M...
A key mechanism weaponized by cancer cells to evade chemotherapeutic treatments in patients with multidrug-resistant cancer is the overexpression of P-glycoprotein (P-gp) on their ce...
Now, a new study by Salk scientists shows how CBN can protect nerve cells from oxidative damage, a major pathway to cell death. “This discovery could one day lead to the development ...
Background Acute respiratory distress syndrome (ARDS) is a life-threatening clinical syndrome whose potential to become one of the most grievous challenges of the healthcare system ...
Much work still needs to be done to establish that cannabis and cannabinoids can fight cancer in humans, including as an adjunct to other therapies like chemo and radiation, and to i...
While cannabidiol (CBD) and tetrahydrocannabinol (THC) are two of the most common phytocannabinoids that currently exist in the market, scientists continue to discover more of them. ...
Cannabis plants produce CBGA, the precursor to three major cannabinoids: tetrahydrocannabinolic acid (THCA), cannabidiolic acid (CBDA), and cannabichromenic acid (CBCA). CBC as a pot...
Article written by Tina MagrabiSenior Content Writer Tina Magrabi is a writer and editor specializing in holistic health. She has written hundreds of articles for Weedmaps where sh...
What is the Endocannabinoid System (ECS)? As most people are already aware of THC and CBD, we’ll be covering the following lesser-known cannabinoids: CBN CBG CBC THCV What is CBN? ...
In 2014, section 7606 of the U.S. Congress Agricultural Act of 2014, the “Farm Bill”, authorized pilot programs on cultivation of industrial hemp, defined as “the plant Cannabis sati...
The primary literature was searched for hemp-nematode papers, resulting in citations from 1890 through 2021. Keywords: Cannabis sativa, Cyst nematodes, Ditylenchus, Hemp, Heterodera ...
Hemp Diseases Hemp diseases are primarily caused by fungi and rarely by bacteria and viruses (Table 1; McPartland, 1997; Kusari et al., 2013; Giladi et al., 2020; Jerushalmi et al.,...
Supplementary Table 1 presents the measured floral cannabinoid concentrations of the immature flower tissues from control plants (day 1) and stress-treated plant (day 6 or day 8) tha...
The response RSD for each pesticide at its LOQ level in the hemp matrix was less than 20%. 1 a Overlay of the response of blank hemp matrix (red) and propiconazole (green) at a level...
Specifically, in this research we acquired hyperspectral images from freshly harvested leaf and flower materials of five cultivars of CBD hemp at five growth stages using a benchtop ...
CBDA is most commonly used by people who prefer the raw and unprocessed form of CBD. You can still find some products that include CBDA in them, but it’s most common to see CBD and C...
Other cannabinoids include Delta-9 THC, the infamous psychoactive element in marijuana, and less popular ones like Delta-8 THC, CBN, CBG, CBDA, and CBGA. What are Cannabinoids? How M...
A key mechanism weaponized by cancer cells to evade chemotherapeutic treatments in patients with multidrug-resistant cancer is the overexpression of P-glycoprotein (P-gp) on their ce...
Cannabinoids. Breakthrough research just released indicates that cannabinoid compounds have the ability to prevent the virus from infecting the respiratory system. The effectiveness ...
In the prediction of total THC content, RPD values > 2 were obtained, which indicates the goodness of the models. The best model to predict CBD content was also obtained without a...
The hemp plant consists of the woody part (44% of the plant weight), fibres (24%), seeds (11%) and other components such as flowers, leaves and dust (21%) [ 1 3 ]. Since each part of...
Based on prior research, we hypothesize that fertility treatments would not significantly change cannabinoid ratio, and that higher N fertility regimes would increase biomass yield. ...
Cannabis sativa L. is an intriguing plant that has been exploited since ancient times for recreational, medical, textile and food purposes. The plant’s most promising bioactive const...
Considering the GC-MS results, the following concentrations of nonintoxicating phytocannabinoids and caryophyllane sesquiterpenes, in 50 μg/mL of FOJ and FOS, respectively, were test...
The differing rates of terpene loss from inflorescence of the same chemotype, but different harvests, is further illustrative of the inherent variability of cannabis inflorescence te...
Figure 3a shows negative correlations, i.e. inverse relationships between the frequency of the reported effect and flavour tags, while Fig. C. Both positive (Panel A) and negative (P...
CBDV is structurally similar to CBD (cannabidiol). Strains that are high in CBD also typically tend to be higher in CBDV. GW reports that CBDV has shown anti-epileptic results “acros...
A non-intoxicating cannabinoid found in the cannabis plant that is similar to cannabidiol (CBD). Cannabidivarin (CBDV) has been known to harmonize the physiological activity of the c...
The primary difference between CBGA and CBD is that CBGA (cannabigerolic acid) is the acidic form of CBG but gets converted into THC or CBD. To produce any common cannabinoids, the “...
Cannabinoids. Breakthrough research just released indicates that cannabinoid compounds have the ability to prevent the virus from infecting the respiratory system. The effectiveness ...
A groundbreaking study from Israel has documented the superior therapeutic properties of whole plant CBD-rich cannabis extract as compared to single-molecule cannabidiol (CBD). The I...
But prompted by parents whose children had responded well to whole plant medicinal cannabis extracts, but not to conventional antiepileptic drugs or purified cannabidiol (CBD oil), m...
Our group settled six formulations combining CBD and terpenes purified from Cannabis sativa L, Origanum vulgare , and Thymus mastichina . CBD is a partial agonist for ...
As a result of its presence in so many common foods and spices, it has been the subject of significant scientific attention over the last couple decades – especially following the di...
Bioluminescence resonance energy transfer (BRET) assay For BRET assay, HEK-293T cells were transiently cotransfected with a constant amount of cDNA encoding for GluN1-RLuc (0.25 μg)...
However, still little is known whether prenatal MAM exposure could affect ECS signaling in the early postnatal days. A total of 20 males from each group (i.e., CNT and MAM, maximum o...
Bioluminescence resonance energy transfer (BRET) assay For BRET assay, HEK-293T cells were transiently cotransfected with a constant amount of cDNA encoding for GluN1-RLuc (0.25 μg)...
However, still little is known whether prenatal MAM exposure could affect ECS signaling in the early postnatal days. A total of 20 males from each group (i.e., CNT and MAM, maximum o...
Formed from the same shiny, resinous trichomes as cannabinoids, cannabis terpenes also bind to the same endocannabinoid receptors located throughout the brain and body. For example, ...
Unsupervised hierarchal clustering of the profiling data revealed that the 124 extracts diverge into five predominant clusters distinguished by their phytocannabinoid composition tre...
What Does CBL Do? Even people who consume only CBD products can fail a THC test due to the residual trace amounts of THC present. For example, there are many ways to use CBD so long ...
What is Delta-8 THC? Delta-8-Tetrahydrocannabinol (Delta-8 for short) is a legal cannabinoid that can give you a heady high while only containing 0.3% THC, the same as CBD. Unfortuna...
What is the Endocannabinoid System (ECS)? As most people are already aware of THC and CBD, we’ll be covering the following lesser-known cannabinoids: CBN CBG CBC THCV What is CBN? ...
Scientists have found more than 100 cannabinoids. The most commonly known cannabinoids are Delta-9 THC and cannabidiol (CBD). There is one CBD product, Epidiolex, that the FDA approv...
CBIS Cannabinoid Research. CBIS CANNABINOID RESEARCH. CBIS Cannabinoid research and development focuses on pharmaceutical distribution, as well as other specific markets. CBIS would ...
The results show that cannflavin A concentrations ranging from 2.5 to 50 μM do not induce significant cytotoxicity compared to their vehicle control, while known chemotherapeutic tre...
A follow-up study demonstrated that this mechanism of HU-331 also works against the other human isoform of topoisomerase II, TOP2B (Wilson et al. 2018). These results indicate that H...
A total of 2 different extraction procedures were performed according to previous published studies [ 30 32 ] to obtain medical Cannabis oil 1 (MCO-1) and MCO-2 (SIFAP and Calvi meth...
The first clinical study was a small, proof-of-concept 11-subject study, where a 3%extract was found to significantly reduce sebum and erythema better than vehicle, suggesting CBD co...