Gene Expression Data Mining Reveals the Involvement of GPR55 and Its Endogenous Ligands in Immune Response, Cancer, and Differentiation

Wnorowski, Wójcik, Maj, Artur Wnorowski, Jakub Wójcik, Maciej Maj

Several endogenous peptides were discovered to activate GPR55 [ 10 ]. As depicted in Figure 3 B, the identified experiments focused on immune activation (55%), response to drug treatment (29%), immune-mediated inflammatory diseases (IMIDs; 10%), cancer (4%), and differentiation (2%).upregulation was observed predominantly in the immune cells (67%) or in whole blood (10%). The experimental conditions that led to the downregulation of GPR55 were identified based on gene expression data ( Figure 2 A). Here, we identified UC as a condition characterized by upregulation of GPR55 and increased PACAP27/38 production. PACAP upregulation was described previously in UC patients [ 56 ], and conditions favoring PACAP27/38 production are reported here.

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