The Dynamic Role of Microglia and the Endocannabinoid System in Neuroinflammation

Young, Alexander P., Department Of Pharmacology, Denovan-Wright, Eileen M., Cecilia Hillard, Natasha L. Grimsey, Julian Romero

Many of the CB 2 receptors were expressed in activated M1 microglia, although astrocytes were also identified as CB 2 receptor positive. As aged brains exhibit a higher proportion of pro-inflammatory microglia compared to young brains, it would be expected for aged brains to contain elevated levels of CB 2 receptors as well. This indicated that the enhanced effect on IL-10 release was mediated by the activation of CB 2 but not CB 1 receptors. Front Cel Neurosci 13, 424. doi:10.3389/fncel.2019.00424 PubMed Abstract CrossRef Full Text Google Scholar Aso, E., Juvés, S., Maldonado, R., and Ferrer, I. Increased Interleukin-6 Expression by Microglia from Brain of Aged Mice.

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