The Dynamic Role of Microglia and the Endocannabinoid System in Neuroinflammation
Young, Alexander P., Department Of Pharmacology, Denovan-Wright, Eileen M., Cecilia Hillard, Natasha L. Grimsey, Julian Romero
| Many of the CB 2 receptors were expressed in activated M1 microglia, although astrocytes were also identified as CB 2 receptor positive. As aged brains exhibit a higher proportion of pro-inflammatory microglia compared to young brains, it would be expected for aged brains to contain elevated levels of CB 2 receptors as well. This indicated that the enhanced effect on IL-10 release was mediated by the activation of CB 2 but not CB 1 receptors. Front Cel Neurosci 13, 424. doi:10.3389/fncel.2019.00424 PubMed Abstract | CrossRef Full Text | Google Scholar Aso, E., Juvés, S., Maldonado, R., and Ferrer, I. Increased Interleukin-6 Expression by Microglia from Brain of Aged Mice. |
Tags:
- Microglia
- Cannabinoid receptor type 2
- Neuroinflammation
- Cannabinoid receptor
- Endocannabinoid system
- Cannabinoid
- Cannabinoid receptor type 1
- Inflammation
- MAPKERK pathway
- Mitogen-activated protein kinase
- Cell signaling
- Amyloid beta
- Neurodegenerative disease
- Receptor (biochemistry)
- Macrophage polarization
- Interleukin 6
- Cytokine
- 2-Arachidonoylglycerol
- Tumor necrosis factor
- Substantia nigra
- Receptor antagonist
- Interleukin 10
- Neurofibrillary tangle
- Putamen
- Tetrahydrocannabinol
- Adenosine A2A receptor
- Huntingtin
- MPTP
- Signal transduction
- Inflammatory cytokine
- Biotechnology
- Neuroscience
- Biochemistry
- Neurophysiology
- Cell biology
- Neurochemistry
- Cell communication