Cannabinoid Receptors in the Central Nervous System: Their Signaling and Roles in Disease

Kendall, Debra A., Department Of Pharmaceutical Sciences, University Of Connecticut, Storrs, Ct, Yudowski, Guillermo A., Department Of Anatomy, Neurobiology

We will introduce the two major receptors, focusing on the CB 1 receptors due to their high expression levels in the CNS; their endogenous ligands or endocannabinoids (eCB) and some synthetic mimetics that activate and modulate their signaling; the signaling pathways that connect this receptor to processes inside the cell; and the role of the CB system in the normally functioning CNS and its alteration or therapeutic modulation in a variety of disease states. Abbreviations AD, Alzheimer’s Disease; AEA, arachidonylethanolamine; 2-AG, 2-arachidonoylglycerol; CB 1 receptors, cannabinoid 1 receptor; CB 2 receptor, cannabinoid 2 receptor; CBD, cannabidiol; CBs, synthetic ligands for CB1/2; CNS, central nervous system; eCBs, endocannabinoids; GPCR, G protein-coupled receptor; HD, Huntington’s disease; MS, multiple sclerosis; TBI, traumatic brain injury. Agonist selective regulation of G proteins by cannabinoid CB 1 and CB 2 receptors. doi: 10.1124/mol.106.029348 PubMed Abstract CrossRef Full Text Google Scholar Multiple sclerosis in adults: management 1-recommendations Guidance and guidelines NICE. Cannabinoid receptors and their ligands: beyond CB 1 and CB 2 .

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