Cannabinoid Receptors in the Central Nervous System: Their Signaling and Roles in Disease
Kendall, Debra A., Department Of Pharmaceutical Sciences, University Of Connecticut, Storrs, Ct, Yudowski, Guillermo A., Department Of Anatomy, Neurobiology
| We will introduce the two major receptors, focusing on the CB 1 receptors due to their high expression levels in the CNS; their endogenous ligands or endocannabinoids (eCB) and some synthetic mimetics that activate and modulate their signaling; the signaling pathways that connect this receptor to processes inside the cell; and the role of the CB system in the normally functioning CNS and its alteration or therapeutic modulation in a variety of disease states. Abbreviations AD, Alzheimer’s Disease; AEA, arachidonylethanolamine; 2-AG, 2-arachidonoylglycerol; CB 1 receptors, cannabinoid 1 receptor; CB 2 receptor, cannabinoid 2 receptor; CBD, cannabidiol; CBs, synthetic ligands for CB1/2; CNS, central nervous system; eCBs, endocannabinoids; GPCR, G protein-coupled receptor; HD, Huntington’s disease; MS, multiple sclerosis; TBI, traumatic brain injury. Agonist selective regulation of G proteins by cannabinoid CB 1 and CB 2 receptors. doi: 10.1124/mol.106.029348 PubMed Abstract | CrossRef Full Text | Google Scholar Multiple sclerosis in adults: management | 1-recommendations | Guidance and guidelines | NICE. Cannabinoid receptors and their ligands: beyond CB 1 and CB 2 . |
Tags:
- Cannabinoid receptor type 2
- Cannabinoid receptor type 1
- G protein-coupled receptor kinase
- Cannabinoid receptor
- G protein-coupled receptor
- Receptor (biochemistry)
- Signal transduction
- Tetrahydrocannabinol
- Synapse
- Arrestin
- Biochemical cascade
- Endocannabinoid system
- 2-Arachidonoylglycerol
- Neurodegenerative disease
- G protein
- Neurotransmitter
- Cell biology
- Neuroscience
- Biochemistry
- Neurochemistry
- Biotechnology
- Neurophysiology
- Cell signaling
- Cell communication
- Biology