New Insights in the Involvement of the Endocannabinoid System and Natural Cannabinoids in Nicotine Dependence

Saravia, Ten-Blanco, Pereda-Pérez, Berrendero, Rocio Saravia, Marc Ten-Blanco, Inmaculada Pereda-Pérez, Fernando Berrendero

Indeed, several studies have revealed the health risks of using these devices, as well as traditional cigarettes and any other tobacco product [ 26 29 ]. On the contrary, more recent studies have shown that activation of CB2R inhibits the rewarding effects of nicotine. Systemic administration of this compound dose-dependently inhibited nicotine self-administration in rats and mice. However, other study showed no changes in the somatic signs of withdrawal due to URB597 treatment [ 146 ]. Given the relevance of the endocannabinoid system in memory and learning [ 158 159 ], its involvement in the cognitive deficits associated with nicotine withdrawal has been investigated.

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