Endocannabinoid-Mediated Control of Neural Circuit Excitability and Epileptic Seizures
Sugaya, Department Of Neurophysiology, Graduate School Of Medicine, The University Of Tokyo, International Research Center For Neurointelligence, Wpi-Ircn, The University Of Tokyo Institutes For Advanced Study, Utias, Kano, Edward S. Ruthazer
Involvement of CB 1 and CB 2 Receptors It has also been reported that, as with DGLα, expression of the CB 1 receptor is affected by epileptogenesis (Figure 2). Taken together, these results indicate that CB 1 receptor signaling at excitatory synaptic terminals in the hippocampus has a suppressive effect on kainate-induced seizures (Table 1). These results indicate that CB 1 receptor signaling in the epileptic brain suppresses the occurrence of spontaneous seizures in the SE model and the absence seizure model (Figure 2 and Table 1). Therefore, CBD might suppress seizures by increasing the levels of AEA and/or 2-AG. Seizure 57, 22–26.
Tags:
- Epileptogenesis
- Cannabinoid receptor type 1
- Epilepsy
- Hippocampus
- Endocannabinoid system
- Cannabidiol
- Cannabinoid
- Inhibitory postsynaptic potential
- Chemical synapse
- Spike-and-wave
- Seizure
- Neurotransmitter
- Cannabinoid receptor type 2
- Synapse
- Brain
- Hippocampus anatomy
- Anticonvulsant
- Hippocampus proper
- TRPV1
- Receptor (biochemistry)
- Neuron
- 2-Arachidonoylglycerol
- Dentate gyrus
- Cell signaling
- Kindling (sedativehypnotic withdrawal)
- Clobazam
- -Aminobutyric acid
- Hippocampal sclerosis
- Physiology
- Cell biology
- Biochemistry
- Neurophysiology
- Neurochemistry
- Neuroscience