Endocannabinoid-Mediated Control of Neural Circuit Excitability and Epileptic Seizures

Sugaya, Department Of Neurophysiology, Graduate School Of Medicine, The University Of Tokyo, International Research Center For Neurointelligence, Wpi-Ircn, The University Of Tokyo Institutes For Advanced Study, Utias, Kano, Edward S. Ruthazer

Involvement of CB 1 and CB 2 Receptors It has also been reported that, as with DGLα, expression of the CB 1 receptor is affected by epileptogenesis (Figure 2). Taken together, these results indicate that CB 1 receptor signaling at excitatory synaptic terminals in the hippocampus has a suppressive effect on kainate-induced seizures (Table 1). These results indicate that CB 1 receptor signaling in the epileptic brain suppresses the occurrence of spontaneous seizures in the SE model and the absence seizure model (Figure 2 and Table 1). Therefore, CBD might suppress seizures by increasing the levels of AEA and/or 2-AG. Seizure 57, 22–26.

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