Coffee & Cannabis


When coffee and cannabis are combined, which effects win out? Adenosine: CB1 Gatekeeper A1 Adenosine Receptors CB1 cannabinoid receptors and A1 adenosine receptors both populate the hippocampus – a region of the brain responsible for many aspects of memory. Endogenous cannabinoids and plant cannabinoids inhibit neurotransmitter release by activating the CB1 receptor. Adenosine, by activating the A1 receptor, reduces the efficacy of THC and other cannabinoids at CB1. When mixed with caffeine, CBD’s effects on adenosine would probably be dwarfed by caffeine’s antagonistic activity at adenosine receptors.

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