Mechanisms of Cannabidiol (CBD) in Cancer Treatment: A Review

Heider, Camren G., Itenberg, Sasha A., Rao, Ma, Wu, Camren G. Heider, Sasha A. Itenberg, Jiajia Rao

with high THC content is cultivated for medical applications and/or recreational use [ Cannabis plants are easy to cultivate, as they do not require a specific type of soil; however, the soil should be at a neutral pH or slightly alkaline [ Cannabis plants and contributes their THC content [ Cannabis sp. They can also be effectively grown in diverse climates and can be used in organic crop rotation [ Cannabis plants and used to obtain various potential health benefits—including cancer treatment and pain management [ Phytochemicals, including phytocannabinoids and non-phytocannabinoids, fromL. Many Cannabis strains contain higher amounts of CBD than THC [ CBD is a major bioactive, non-intoxicating cannabinoid inplants. Cannabinoids may exert their anticancer effects, as well as many of their other biological activities, primarily by binding to a group of G protein-coupled receptors, known as type 1 and 2 cannabinoid receptors (CB1 and CB2, respectively) [ 5 ]. THC exerts psychotropic effects due to its high affinity with cannabinoid receptor (CB1) in the brain, whereas non-psychotropic cannabinoids, such as CBD, have a lower affinity with CB1, which can be activated to promote the positive effects of CBD [ 10 ].

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