Dos(e)Age: Role of Dose and Age in the Long-Term Effect of Cannabinoids on Cognition

Zamberletti, Rubino, Erica Zamberletti, Tiziana Rubino

Almost 4% of the global population aged between 15 and 64 years used cannabis at least once in the last year, according to the 2021 World Drug Report [ 1 ]. Outside of teens, older adults aged ≥65 years currently represent the fastest-growing population of cannabis users. Recently, an increased prevalence of cannabis use has also been described among pregnant women. Accordingly, a recent study showed that pregnant women with nausea and vomiting during pregnancy had nearly 2–4 times greater odds of prenatal cannabis use [ 12 ]. The increased prevalence of cannabis use reported in these sensitive population subgroups highlights the need to examine the effects of cannabis use on cognitive function across ages.

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