Because animal studies offer more detailed mechanistic information about the pathobiology of neuroinflammation and remyelination than is possible with human studies, the second branc...
We used two indicators to analyze the movement of this part (Figure 2B): 1) the distance between Y2945.58 and Y3977.53, the two conserved residues in class A GPCRs that lay far apart...
Oncogenic and Tumor Suppressor Effects of miRNAs via Cannabinoid System Aside from the cannabinoid system modulating miRNA expression, miRNAs can also regulate the cannabinoid syste...
Gene array analysis of CBG and CBD applied topically to a 3D human skin model demonstrates that CBG outperforms CBD, selectively targeting collagen, elastin and other key skin health...
Other efforts to study the effect of cannabinoids and the endocannabinoid system on cancer progression have included analyses of cannabinoid receptor expression levels in cancer tiss...
(d) The agonistic effect of HU308 on CB2R in HEK293-CB2 cells. Determination of Proliferation, ALP Activities, and Bone Mineralized Nodules of Osteoblasts The BMSCs cells were inocu...
26 , 27 , 28 However, this is not well studied in cancer patients. The remaining six studies were NRSI (n = 157) assessing the effects of cannabis or cannabinoid treatment on appetit...
From the training molecules, generative models study and summarize a probability distribution to sample new molecules that are similar to the training data [24,25]. The training proc...
Although CB2R is enriched in the immune system, we observed CB2R expression in microglia, as might be expected, and neurons in different mouse brain regions (Liu et al., 2020a). We f...
Significant morphological differences were found between plants and chemotypes. These analyses were performed on five plants per breeding population (N = 5). The measurements were do...
These models showed a predictive performance of Q2 = 0.62 and Q2 = 0.72 for the CB1 and CB2 QSAR models, respectively. Our study aimed to predict CB2-selectivity for molecules identi...
This review summarizes the main findings highlighting the involvement of CB2R in different physiological processes such as stress response, emotional reactivity, and cognitive proces...
These effects are mediated via the binding of BCP to CB2R, which activates PGC1-α and promotes the interaction between PPAR-γ and different transcriptional factors, such as PPAR-α le...
Cannabinoids Effects in Cognitive and Motor Impairment in Traumatic Brain Injury (TBI) In are presented in vivo studies published between 2009 and 2019 that evaluate the cannabinoid...
15 a: colorless crystals, C9H10O3, Mr=166.17, crystal size 0.30×0.10×0.05 mm, monoclinic, space group P21/c (No. 15 b: colorless crystals, C12H14O3, Mr=206.23, crystal size 0.50×0.30...
TABLE 1 ABN-CBD Ameliorates Hyperinsulinemia, Protects Beta Cells From DIO-Induced Apoptosis, Decreases Inflammation, and Stimulates Beta Cell Proliferation After 2 weeks of treatm...
For binding assays, radioligand ([3H]-CP55,490, PerkinElmer, Waltham, MA, USA), non-radiolabelled drugs, and P2 membrane preparations were diluted in binding buffer (50 mM HEPES pH 7...
CB2-selective agonists”. Mixed CB1/CB2 Agonists Most known synthetic agonists of cannabinoid receptors show little selectivity between CB1 and CB2 [21], but exhibit stronger affinit...
To replicate and extend work in the existing literature, the objectives of the replicated field trials involving 30 high-CBD cultivars in this experiment were to: Assess variation i...
Medicines with cannabinoids in them (cannabinoid-based medicines) either contain THC or CBD or both. In: Cannabis and Cannabinoids. Cannabis. In: Cannabis and Cannabinoids. Cannabis.
Although no clinical studies to our knowledge have yet reported long-lasting consequences on GABAergic and glutamatergic systems following adolescent cannabis exposure, aberrations h...
Optimal fertilizer rates were observed at 50 ppm N, while increased fertilizer rates significantly reduced plant growth, biomass accumulation, and cannabinoid concentrations. Five es...
Cannabinoid type 1 receptor surface expression in neurons is highly polarized to axons and presynaptic sites, where ligand binding results in the downregulation of presynaptic releas...
Marijuana. Cell 2019, 176, 459–467. The cannabinoid receptors. Cells 2021, 10, 1282. Cell.
However, this effect is not always observed, with some studies reporting no effect on birth weight (37–42). These findings highlight the importance of investigating the impact of exo...