Targeting Cannabinoid Receptors: Current Status and Prospects of Natural Products
Dongchen An | Steve Peigneur | Louise Antonia Hendrickx | Jan Tytgat | Louise Antonia
CB2-selective agonists”. Mixed CB1/CB2 Agonists Most known synthetic agonists of cannabinoid receptors show little selectivity between CB1 and CB2 [21], but exhibit stronger affinity for cannabinoid receptors compared to endo- and phytocannabinoids [65]. HU-210 ( a), an example of a classical synthetic cannabinoid, is a highly potent cannabinoid receptor agonist, and its potency and affinity at cannabinoid receptors exceed those of many other cannabinoids [66]. Both compounds bind with much higher affinity to CB2 than to CB1, exhibit marked potency as CB2-selective antagonists and behave as inverse agonists that can produce inverse cannabimimetic effects at CB2 by themselves [66]. These peptides can be regarded as novel cannabinoids because they exhibit activity at cannabinoid receptors and have distinct structures from phytocannabinoids and synthetic cannabinoids.
Tags:
- Cannabinoid receptor 2
- Cannabinoid
- Dronabinol
- Cannabinoid receptor 1
- Tetrahydrocannabinol
- Cannabinol
- Receptor antagonist
- Cannabidiol
- RVD-Hpα
- Allosteric regulation
- Cannabinoid receptor antagonist
- Medical cannabis
- Anandamide
- Ligand (biochemistry)
- Cannabinoid receptor
- Allosteric modulator
- Synthetic cannabinoids
- Receptor (biochemistry)
- Neurochemistry
- Biochemistry
- Cell biology