Endocannabinoid System and Migraine Pain: An Update
AEA is rapidly degraded by fatty acid amide hydrolase (FAAH) enzyme and its levels can be modulated in the peripheral and central nervous system (CNS) by FAAH inhibito...
Combination of cannabidiol with low‑dose naltrexone increases the anticancer action of chemotherapy in vitro and in vivo
These receptors feed into and interact with central signalling cascades that determine the ease by which cells engage in apoptosis, and can be used as a way to prime cancer cells to ...
Cannabinoids and COVID-19
The team’s research focused specifically on the role of cannabinoid acids – CBD-A, CBG-A, and THC-A. You’ve been studying hemp for years. Think of the mass spectrometer as the magnet...
Bod Australia to start long Covid-19 trial using medicinal cannabis in UK
Bod Australia is to start a clinical trial of its medicinal cannabis product, MediCabilis 5%, to treat long Covid-19 after the UK Medicines and Healthcare Products Regulatory Agency ...
The Future of High-CBD Hemp
“If you are living in a world that is predicated on perpetual growth, and the one thing that drives this perpetual growth are these underlying environmental resources, you can’t keep...
Research Breakthrough: Cannabis & Autism
And then we found about 31 biomarkers in our group of patients and we measured their biomarkers for autism that actually showed some relevance to the autism and to the cannabis treat...
Medicinal Terpenes
As a result of its presence in so many common foods and spices, it has been the subject of significant scientific attention over the last couple decades – especially following the di...
Medical Uses of CBD
The earliest reference to the therapeutic use of cannabis dates back to 2700 BC in ancient China, “the land of hemp and mulberry.” Cannabis (“Ma”) was subsequently included in the Pe...
ICRS 2019: CBD for Anxiety, Cancer, Heart Disease, Addiction…
The study found that CBD limited the damage caused by induced brain injury: “ CBD significantly reduces infarct volume and improved early functional outcome in experimental stroke in...
Gut Microbiota & the Endocannabinoid System
Cannabis for Gut Health Interactions between gut microbiota and the endocannabinoid system were first explored in 2010. What’s more, microbiome health may be modified and even impro...
Endocannabinoid System as a Promising Therapeutic Target in Inflammatory Bowel Disease – A Systematic Review
At the same time, CBD has been shown to reduce the activity of B cells, activate T cells (by increasing the level of apoptosis), and induce Treg cells to inhibit the production of cy...
Endocannabinoid Discovery Timeline
1993: CB -2 Receptor Scientists identified a second type of cannabinoid receptor – “CB2” – which is present throughout the immune system, the peripheral nervous system, metabolic ti...
Encouraging Cancer Research
Much work still needs to be done to establish that cannabis and cannabinoids can fight cancer in humans, including as an adjunct to other therapies like chemo and radiation, and to i...
Coffee & Cannabis
When coffee and cannabis are combined, which effects win out? Adenosine: CB1 Gatekeeper A1 Adenosine Receptors CB1 cannabinoid receptors and A1 adenosine receptors both populate th...
CBD User’s Guide
What is CBD ? Which Is Better CBD or THC ? Begin with a small dose of high CBD/low THC oil, especially if you have little or no experience with cannabis. But single-molecule CBD is l...
CBD & the Psychedelic Receptor
The activation of a G-protein coupled receptor from a signal outside the cell releases a second messenger molecule into the cell’s interior. CB1 cannabinoid receptors – which are act...
CBD & Its Entourage
The plant is also rich in compounds called terpenes and flavonoids, which work together with CBD and THC to create an “entourage effect” that is greater than the effect of any one of...
CBD Dentistry
Several toothpaste manufacturers have taken note of research showing that CBD and other plant cannabinoids have antimicrobial properties relevant to dental care.1 Colgate has already...
CBD & Cannabis for Endometriosis
“My pain kind of started to get worse in my late teens, early 20s,” recalls Carrie. I just feel better when I’m taking it.” Endometriosis & Endocannabinoid Dysfunction While ca...
Cannabis & the Immune System: A Complex Balancing Act
It gets even more complicated when we consider that the effects of cannabis are mediated primarily by the endocannabinoid system, which scientists believe interacts with all biologic...
Cannabis and Cannabinoids (PDQ®)–Patient Version
What are cannabinoids? Some other states have legalized only one ingredient in Cannabis, such as cannabidiol (CBD), and these states are not included in the map. When taken by mouth,...
Cannabis and Cannabinoids (PDQ®)–Health Professional Version
[22] Similarly, a study of a subset of cancer patients in the Minnesota medical Cannabis program explored changes in the severity of eight symptoms (i.e., anxiety, appetite loss, dep...
Cannabis and Cancer Part 2: Scientists Look for Ways to Increase Knowledge About Cannabis with Help from People with Cancer
At the same time, inconsistencies in state policies conflict with federal law, which itself, scientists said at a recent NCI-sponsored Cannabis, Cannabinoids, and Cancer Research Sym...
Cannabis and Cancer, Part 1: Despite Lack of Evidence, Cannabis Products Being Widely Used
In fact, while many patients say they experience symptom relief with cannabis products, there is no clear evidence on the benefits or potential harms, how cannabis interacts with the...
Caffeine, ADHD & the CB1 Receptor
Dopamine, cannabinoid, and adenosine receptors signal together to coordinate attention and impulsivity. But the increased impulsiveness induced by WIN in this rat experiment was prev...