The assessment of potential interactions must be carried out in both directions: that is, both the effects of cannabinoids on other drugs and the effects of other drugs on cannabinoi...
Psychosis is a characterizing feature of many mental disorders that dramatically affects human thoughts and perceptions, influencing the ability to distinguish between what is real a...
The PLOS Data policy requires authors to make all data underlying the findings described in their manuscript fully available without restriction, with rare exception (please refer to...
Methods Cell culture The HEK293TR cell line was used for the generation of stable cell lines expressing either the CB1R and CB2R and the Gi-CASE biosensor. The response kinetics of...
To understand the effect of each receptor mutant on allosteric ligand G protein dissociation, we first evaluated the effect of mutations within putative allosteric binding sites on o...
Cell cytotoxicity was assessed for eight of the isolated compounds ( B). As shown in , among the eight compounds isolated from CC, 3-O-caffeoylquinic acid (compound 2, −12.3 kcal/mol...
Virtual Screening To estimate the binding affinity of the investigated drugs towards CB1R, a molecular docking analysis was performed by means of the MOE (Molecular Operating Enviro...
However, the pH values of biochar materials reportedly range from 3.5 to 10.3 (Fornes et al. 2015; Khodadad et al. 2011; Nemati et al. 2015; Spokas et al. 2012) and may potentially n...
Inclusion and exclusion criteria Studies that used animal models to assess the effects of pharmacological and/or genetic manipulation of the classical cannabinoid CB1 and/or CB2 rec...
The inhibition of CB1 receptors [72] and activation of CB2 receptors [28] retarded cardiac fibrosis following MI and improved the cardiac function. [Google Scholar] [CrossRef] [PubMe...
Within a few weeks, the dog exhibited significant improvement in dermatological signs, accompanied by a concurrent improvement in liver function. Figure 2 The patient’s initial pres...
Cannabinoid hyperemesis syndrome. Cannabinoid hyperemesis syndrome. A gut gone to pot: a case of cannabinoid hyperemesis syndrome due to K2, a synthetic cannabinoid. [PMC free articl...
Under a Creative Commons license open access Abstract Type-2 cannabinoid receptor (CB2R) is a member of the G protein-coupled receptor superfamily with various biological activiti...
Type 2 immunity in the lung protects against pathogenic infection and facilitates tissue repair, but its dysregulation may lead to severe human diseases. Notably, cannabis usage for ...
There is growing interest in using cannabinoids across various clinical scenarios, including pain medicine, leading to the disregard of regulatory protocols in some countries. Legisl...
The phytocomplex of Cannabis is made up of approximately 500 substances: terpeno-phenols metabolites, including Δ-9-tetrahydrocannabinol and cannabidiol, exhibit pharmacological acti...
The Lion Poll survey was conducted to better understand patients’ views on cannabinoid awareness, reporting of use to HCPs, and perceptions of cannabinoid safety when compared to oth...
In parallel, it has been demonstrated that the internalization of the cannabinoid CB1 receptor can be induced by the peptide orexin A when the orexin OX1 receptor is co-expressed alo...
Pain 2020, 161, 1976–1982. Pain 2001, 93, 239–245. Pain 2002, 96, 253–260. Pain 2004, 109, 124–131. Cannabis Cannabinoids 2020, 3, 25–60.
In Vitro Human Skeletal Muscle Cancer Cachexia Cell Model Is Established Using Cancer Conditioned Media Which Induces Significant Degeneration of Mature Myotubes Primary human skele...
This study investigates the bioengineering potential of the marine diatom Phaeodactylum tricornutum through the introduction of cannabis genes, specifically, tetraketide synthase (TK...
Conversely, activation of CB receptors during influenza infection led to reduced immune cell recruitment but increased viral replication, hinting at their involvement in viral replic...
The involvement of the ECS in modulating psychiatric disorders appears to be due to two G protein-coupled receptors, cannabinoid receptor type-1 (CB1R) and cannabinoid receptor type-...
In the present study, we hypothesized that the synthetic cannabinoid (R)-5-Fluoro-ADB could modulate the endothelial cells’ viability and brain cells’ angiogenesis rate. Results Syn...
Statistical evaluation of the dependence of growth inhibition on individual phytocannabinoids Statistical analyses based on stepwise regression models of the dependence of the MIC o...