Now, about 80% of people who use heroin misused prescription opioids first [9] and most opioid overdose deaths involve synthetic opioids [10]. Observational research has explored the...
Starting from a previously described in vitro activity-based CB1 assay, this study reports on a novel application of this assay to screen for cannabinoid activity in herbal products....
These wavelengths are compatible with the emission spectra of Terbium [24], the lanthanide used for CBRs labeling in the developed Tag-lite® binding assay. CELT-335 HTRF Assay Valida...
Abstract A novel and major cannabinoid (epicannabidiol hydrate) present in hemp plants and oils was isolated and characterized by a combination of flash chromatography and liquid ch...
Synthetic cannabinoids have been developed to elicit responses by cannabinoid receptors. A compound library of over 300 synthetic cannabinoids was screened against the strain. (a) Sc...
The results confirmed that CB2 expression was significantly reduced in BC tissues than paracancerous tissues (Figure 1B,C). Meanwhile, CB2 protein expression was lower in BC tissues ...
As agonist binding leads to the activation of CB1, active and inactive structures have distinct N-terminus feature values. For CB1, I1 and I2 are structurally similar to the inactive...
For participants taking multiple cannabis products, the cannabinoid profile was determined by the overall THC:CBD concentration of all products. There is no association between pain ...
We tested the effect of SGIP1 deletion on CB1 signaling in autaptic cultures. Autaptic hippocampal neurons were cultured as described previously34,35. To address these questions, we ...
The C5-alkyl side chain cannabinoids Δ9-THC and Δ9-THCA were detected in every sample, CBDA and CBGA were reported in 98% of samples, CBD in 96% of samples, followed by CBN in 95%, C...
Cancer 2021, 9, e001643. Cancer 2014, 134, 2853–2864. Cell. The Anti-Tumorigenic Role of Cannabinoid Receptor 2 in Colon Cancer: A Study in Mice and Humans. The Anti-Tumorigenic Role...
Only the sessions using flower products (60.4% of total sessions) were included in the dataset, and 6.7% of the flower sessions included laboratory-provided information on the produc...
TABLE 3 For the control and consortium treatment for the recommended nutrient regime, n was 44 whereas for Pseudomonas sp. treatments n was 48. n was 48 for all four treatments unde...
In our continual interest to explore new bioactivities of the reported natural metabolites, 235 were depsidone derivatives, and 217 of them were reported to have naturally originated...
LEI-102 did not bind CB1R, thereby showing at least 1000-fold selectivity (Supplementary Table 3). In G protein activation assays, LEI-102 activated the receptor as a partial agonist...
In this research, we seek i) to evaluate the relationship of the clinical delivery of cannabinoid-based medicine for anxiety, depression and sleep scores by utilizing machine learnin...
Preclinical studies suggest that the ɑ7 nAChR subtype may play a role in modulating the reinforcing and discriminative stimulus effects of cannabinoids, while the ɑ4β2 * nAChR subtyp...
TABLE 1 TABLE 2 THC and CBD potency A large proportion of inhalation products were categorized as very strong THC products (percent of products with ≥20%/g THC and average THC): d...
Cell 2020, 181, 219–222. Cell 2022, 185, 2899–2917.e31. Cell 2013, 153, 86–100. Cell 2015, 161, 1681–1696. Cell Rep. 2018, 24, 1523–1535.
We hypothesized that both the child’s comprehension of treatment and the parental treatment expectation would contribute to higher placebo response in children with ASD. Placebo Resp...
Pain 2003, 106, 337–345. Pain 1992, 50, 133–149. Pain 2022, 26, 1221–1233. Pain 2016, 17, 739–744. Pain 2022, 26, 310–335.
Key to this new protocol was the observation that receptor phosphorylation is highly unstable during routine immunohistochemistry and that for many GPCRs inclusion of protein phospha...
Some genes, such as PT6, GPP4, AAE5, OAC1, and OAC2, were expressed only in S1 and S4. In addition, we found that the expression of CsHATs and CsHDACs genes were significantly associ...
Both promoters were activated after treatment with SA (Fig. Our study also indicates that the promoters of CsPT1 and CsPT4 are responsive to different hormones, except for ABA and SA...
Similar patterns were also observed in other regions of the hippocampus between structural and idiopathic epilepsy groups, however with no difference in respect to the control group....