A Humanized CB1R Yeast Biosensor Enables Facile Screening of Cannabinoid Compounds
Colleen J. Mulvihill | Joshua D. Lutgens | Jimmy D. Gollihar | Petra Bachanová | Caitlin Tramont | Edward M. Marcotte | Andrew D. Ellington | Elizabeth C. Gardner | Colleen J | Joshua D
Synthetic cannabinoids have been developed to elicit responses by cannabinoid receptors. A compound library of over 300 synthetic cannabinoids was screened against the strain. (a) Screen of CB1R with synthetic cannabinoid compounds at 1 µM and 10 nM concentrations. Yeast Transformations The yeast background strain was BY4741 (See yeast strain list). Yeast 2000, 16, 11–22.