The RPMI 1788 cell line, used as normal cells, was treated with BCP at concentrations of 50 and 100 μM for 24 h, thus demonstrating that BCP did not affect the proliferation of norma...
In 2014, section 7606 of the U.S. Congress Agricultural Act of 2014, the “Farm Bill”, authorized pilot programs on cultivation of industrial hemp, defined as “the plant Cannabis sati...
Figure 2 Structural and dynamical differences between wildtype and mutant CB1 for each activation state. (A) For each activation state, all residues are colored as blue according to ...
To our knowledge, it is the first research about the effect of ACEA and its cannabinoid CB1 receptor subtypes on nuclear receptors (NR4A) in skeletal muscles, and it characterizes a ...
In addition, recent studies have shown that the induction of autophagy is associated with these apoptotic effects and is involved in the toxicity of cannabinoid compounds to cancer c...
The characterization and inclusion behavior of inclusion complex of amantadine conjugated cannabinoid (AD-CBD) and biotin-ethylenediamine-β-cyclodextrin (BIO-CD) in solution and soli...
This indicates that an increase in AEA during exercise might be one of the factors involved in the exercise-induced increase in peripheral BDNF levels and that AEA high levels during...
Treatments of the first experiment of male flowers induction on female plants of Cannabis sativa. Number of male flowers per plant and number of germinated pollen cells in vitro afte...
This receptor was identified and cloned from HL60 cells [ 3 ] and was initially considered as ‘peripheral cannabinoid receptor’ due to its wide distribution in peripheral cells and t...
CBG seems to be a potent TRPM8 antagonist (IC50 = 0.16 ± 0.02), which suggests it may have a therapeutic effect in these types of cancers [ 72 ]. From this class of phytocannabinoids...
On the other hand, the intraplantar injection of the CB 2 cannabinoid receptor antagonist AM630 (100 μg/paw) did not significantly reduce the antinociceptive effect of kahweol (80 μg...
Editorial on the Research Topic The Endocannabinoid System: Filling the Translational Gap Between Neuroscience and Psychiatry Translational research has become a priority in every ...
In addition, after administration of different doses of ethanol, a marked increase of tyrosine hydroxylase (TH) gene expression in the VTA and MOr in the NAcc was observed. In contra...
Although it has been shown that CBD has anti-cancer effects on cancer cells, not much is known about the effect of CBD on cancer stem cells. Here, we show that CBD reduced viability ...
Background Acute respiratory distress syndrome (ARDS) is a life-threatening clinical syndrome whose potential to become one of the most grievous challenges of the healthcare system ...
Concentration values in healthy, normal-weight females (F,= 76) and males (M,= 45) ranged in the following intervals: AEA, 0.40–1.65 pmol/mL (F) and 0.41–1.88 pmol/mL (M); 2-AG, 0.69...
Considering the GC-MS results, the following concentrations of nonintoxicating phytocannabinoids and caryophyllane sesquiterpenes, in 50 μg/mL of FOJ and FOS, respectively, were test...
Bioluminescence resonance energy transfer (BRET) assay For BRET assay, HEK-293T cells were transiently cotransfected with a constant amount of cDNA encoding for GluN1-RLuc (0.25 μg)...
As described for the endocannabinoids, the overall pharmacological action of the minor cannabinoids often results from binding at both cannabinoid and “off target” receptors. Althoug...
Introduction i /G o protein) [ The G-protein-coupled receptors (GPCRs), containing about 800 members, are the largest membrane protein family known in the human body [ 1 ]. Although...
Several endogenous peptides were discovered to activate GPR55 [ 10 ]. As depicted in Figure 3 B, the identified experiments focused on immune activation (55%), response to drug treat...
The inflammatory response is one of the major features of brain damage in the case of secondary injury. The anti-inflammatory effects of LXs and ATLs in TBI appear to be via binding ...
ARDS was induced in mice as described previously [ 9 28 ]. To that end, we measured the levels of SCFAs in Naïve, SEB + VEH and SEB + AEA and we found that butyric acid, valeric acid...
Thus, epilepsy syndromes include not only seizures, but also several comorbid conditions related to behavioral and psychiatric disorders such as cognitive impairments, depression, an...
This process is impaired during later stages of AD and the increased levels of tau lead to enhanced activation of microglia [ 59 ]. However, most of the studies investigate the overa...