cannabinoid.data-1.science

Microglial Cannabinoid CB2 Receptors in Pain Modulation

The biological effects of these cannabinoids are mainly mediated by two endocannabinoid receptors, cannabinoid receptors 1 (CB1R) and 2 (CB2R). 2-AG can not only activate CB1R, but a...

Human Astrocyte Spheroids as Suitable In Vitro Screening Model to Evaluate Synthetic Cannabinoid MAM2201-Induced Effects on CNS

Cell 2012, 148, 1039–1050. Cell 2010, 141, 859–871. Cell. Cell. Cell 2013, 155, 1154–1165.

Exploring the Potential of Cannabinoid Nanodelivery Systems for CNS Disorders

The databases were questioned for “cannabinoids + nanosystems” “cannabinoids + nanoparticles” “cannabinoids + drug delivery systems”. Lipid Components in Self-Emulsifying Drug Delive...

Exogenous application of stress-related signaling molecules affect growth and cannabinoid accumulation in medical cannabis (Cannabis sativa L.)

Our results can be applied to improve the cultivation of medical cannabis varieties, enhancing plant growth and cannabinoid yields. Some treatments affected the production of cannabi...

Efficient Synthesis for Altering Side Chain Length on Cannabinoid Molecules and Their Effects in Chemotherapy and Chemotherapeutic Induced Neuropathic Pain

by Wesley M. Raup-Konsavage 1,† , Diana E. Sepulveda 1,2,†, Daniel P. Morris 1, Shantu Amin 1, Kent E. Vrana 1, Nicholas M. Graziane 1,2,* and Dhimant Desai 1,* 1 Dep...

Comparison of the Cannabinoid and Terpene Profiles in Commercial Cannabis from Natural and Artificial Cultivation

We analyzed three samples of each (n = 3) for both indoor and outdoor samples. We identified 9 monoterpenes and 14 sesquiterpenes in CP groups and 10 monoterpenes and 15 sesquiterpen...

Cannabinoid receptor 2 plays a pro-tumorigenic role in non-small cell lung cancer by limiting anti-tumor activity of CD8+ T and NK cells

In line with our mouse data, CB1 and CB2 expression were not only seen in lung cancer cells, but also in infiltrated immune cells, such as CD3+ T and CD8+ T cells, NKp46/NCR1+or CD56...

CANNabinoid Drug Interaction Review (CANN-DIR™)

The CANNabinoid Drug Interaction Review (CANN-DIR™) is a free web-based platform that has been developed to screen for potential drug-drug interactions from the perspective of how a ...

Cannabinoid Compounds as a Pharmacotherapeutic Option for the Treatment of Non-Cancer Skin Diseases

PPARγ was found to be activated by THC [76] and CBD [77]. In addition to the two cannabinoid receptors, human keratinocytes have also been shown to express TRPV1 [55]. Human keratino...

Cannabinoid Biosynthesis Using Noncanonical Cannabinoid Synthases

The hypothesis of the study follows that those enzymes “similar” to Q8GTB6 may catalyze the production of cannabinoids such as THCA (2); enzymes “different” from Q8GTB6 may catalyze ...

A Colorimetric Method for the Rapid Estimation of the Total Cannabinoid Content in Cannabis Samples

The reaction and detection conditions have been established according to the results obtained for the individual cannabinoids Δ9-tetrahydrocannabidiol (THC), cannabidiol (CBD), and c...

Voltage dependence of the cannabinoid CB1 receptor

For several GPCRs, it has been proposed that voltage dependence is also agonist specific (Sahlholm et al., 2008b; Navarro-Polanco et al., 2011; Rinne et al., 2015; Ruland et al., 202...

Too Dense or Not Too Dense: Higher Planting Density Reduces Cannabinoid Uniformity but Increases Yield/Area in Drug-Type Medical Cannabis

Inflorescence yield production per cultivation area (gDW/m2) was higher (by 28–78%) in the higher density treatment than in the lower density treatments in the control, “BBLR” and “d...

Therapeutic Use of Cannabis in Inflammatory Bowel Disease

Ninety-one percent of patients indicated improvement of IBD symptoms with cannabis use; 83.9% reported improved abdominal pain, 76.8% indicated improved abdominal cramping, 48.2% had...

The Role of Cannabinoid Type 2 Receptors in Parkinson’s Disease

Moreover, the alterations in the expression of CB2 receptors observed in brain tissues from PD animal models and PD patients suggest the potential value of CB2 receptors as possible ...

The Enteric Glia and Its Modulation by the Endocannabinoid System, a New Target for Cannabinoid-Based Nutraceuticals?

Cannabinoids are molecules that act on the endogenous cannabinoid system (ECS), also known as the endocannabinoid system, and are usually divided into three main groups: phytocannabi...

The Effect of Harvest Date on Temporal Cannabinoid and Biomass Production in the Floral Hemp (Cannabis sativa L.) Cultivars BaOx and Cherry Wine

Linear regression for the effect of cultivar and total potential THC (A) and total THC (B) on total CBD. Plants 2022, 11, 140. The Effect of Harvest Date on Temporal Cannabinoid and ...

The Cytotoxic Effect of Isolated Cannabinoid Extracts on Polypoid Colorectal Tissue

by Dana Ben-Ami Shor 1,* , Ilan Hochman 2, Nathan Gluck 1 , Oren Shibolet 1 and Erez Scapa 1 1 Department of Gastroenterology, Tel-Aviv Sourasky Medical Center, Tel-Aviv,...

Targeting the cannabinoid system to counteract the deleterious effects of stress in Alzheimer’s disease

Involvement of stress circuits in Alzheimer’s disease neuropathology Postmortem evidence Braak and colleagues have suggested that the LC is amongst the earliest brain regions invol...

Synthetic cannabinoid WIN 55,212–2 inhibits growth and induces cell death of oral and pancreatic stem-like/poorly differentiated tumor cells

We report here that synthetic cannabinoid WIN 55,212–2 inhibits tumor cell proliferation and induces cell death of oral and pancreatic tumor cells, and the effect is much more pronou...

Profiling Cannabinoid Contents and Expression Levels of Corresponding Biosynthetic Genes in Commercial Cannabis (Cannabis sativa L.) Cultivars

To quantify the content of neutral cannabinoids in Cannabis plants, new heating decarboxylation conditions were adopted using reference mixtures of acidic and neutral cannabinoids, a...