Cannabinoid Compounds as a Pharmacotherapeutic Option for the Treatment of Non-Cancer Skin Diseases


Robert Ramer | Burkhard Hinz


PPARγ was found to be activated by THC [76] and CBD [77]. In addition to the two cannabinoid receptors, human keratinocytes have also been shown to express TRPV1 [55]. Human keratinocytes have also been shown to express PPARα/γ/δ receptors and GPR55 [55]. Regulation of the Endocannabinoid System in Skin Diseases 3.3.1. In addition, AEA and 2-AG have been reported to be reduced in keratinocytes from psoriasis patients, while PEA levels are increased [7].

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