Microglial Cannabinoid CB2 Receptors in Pain Modulation
Kangtai Xu | Yifei Wu | Zhuangzhuang Tian | Yuanfan Xu | Chaoran Wu | Zilong Wang
The biological effects of these cannabinoids are mainly mediated by two endocannabinoid receptors, cannabinoid receptors 1 (CB1R) and 2 (CB2R). 2-AG can not only activate CB1R, but also activate CB2R expressed on microglia. The activation of CB2R can reduce pain signaling by regulating the activity of spinal microglia and inhibiting neuroinflammation. [Google Scholar] [CrossRef] [PubMed] Stella, N. Endocannabinoid signaling in microglial cells. [Google Scholar] [CrossRef] [PubMed] Xu, J.; Tang, Y.; Xie, M.; Bie, B.; Wu, J.; Yang, H.; Foss, J.F.