Review of Nematode Interactions with Hemp (Cannabis Sativa)
The primary literature was searched for hemp-nematode papers, resulting in citations from 1890 through 2021. Keywords: Cannabis sativa, Cyst nematodes, Ditylenchus, Hemp, Heterodera ...
Receptor-targeted nanoparticles modulate cannabinoid anticancer activity through delayed cell internalization
Regarding previous works, the results of size and ZP of the plain PLGA NPs and THC-PLGA NPs here presented correlate with them11,17,18,19. The similar values of size and ZP of plain ...
Neurological Benefits, Clinical Challenges, and Neuropathologic Promise of Medical Marijuana: A Systematic Review of Cannabinoid Effects in Multiple Sclerosis and Experimental Models of Demyelination
Certainty of Evidence for Medical Marijuana Effects on MS Symptom Outcomes This systematic review of the literature evaluated the evidence for benefits of medical marijuana treatmen...
Medical Cannabis in Pediatric Oncology: Friend or Foe?
Studies confirming these or other molecular anti-cancer effects of cannabinoids in pediatric cancer cells are scarce, and given the differences between pediatric and adult tumors and...
MD Simulations Revealing Special Activation Mechanism of Cannabinoid Receptor 1
We used two indicators to analyze the movement of this part (Figure 2B): 1) the distance between Y2945.58 and Y3977.53, the two conserved residues in class A GPCRs that lay far apart...
Interaction of Glia Cells with Glioblastoma and Melanoma Cells under the Influence of Phytocannabinoids
All treatments did not affect spheroid size at 70 h. During the formation of 3D aggregates, the size and shape of spheroids have been shown to be primarily determined by cell–cell an...
Endocannabinoid-Mediated Control of Neural Circuit Excitability and Epileptic Seizures
Involvement of CB 1 and CB 2 Receptors It has also been reported that, as with DGLα, expression of the CB 1 receptor is affected by epileptogenesis (Figure 2). Taken together, these...
Dos(e)Age: Role of Dose and Age in the Long-Term Effect of Cannabinoids on Cognition
Almost 4% of the global population aged between 15 and 64 years used cannabis at least once in the last year, according to the 2021 World Drug Report [ 1 ]. Outside of teens, older a...
Converting Sugars into Cannabinoids—The State-of-the-Art of Heterologous Production in Microorganisms
The cells are then sent to a settling tank (ST-101) in which ethyl acetate is used with a 2:1 ratio to resuspend the cells and subsequently promote liquid-liquid extraction. The biph...
Comparison of nabiximols versus oral dronabinol for pain
Superior analgesic effects compared with placebo were demonstrated in randomized clinical trials (RCTs)15–19 and in a large observational study.20 A recent meta-analysis of nine RCTs...
Clinical Data on Canabinoids: Translational Research in the Treatment of Autism Spectrum Disorders
The number of participants (patients included) shows great variability among the analyzed studies. Another study [ 61 ] (p. 1286) published in 2018 evaluated that 60 children with au...
Chronic Pain and the Endocannabinoid System: Smart Lipids – A Novel Therapeutic Option?
There is evidence that also other non-CB1R and non-CB2R (GPR18, GPR119, and GPR55) are involved in the signaling of the ECS [18]. AEA and 2-AG can also activate other receptors, such...
Cannabinoids, their cellular receptors, and effects on the invasive phenotype of carcinoma and metastasis
60 Cannabinoids have been shown to have varying effects on the ability of tumors to establish a metastasis, although from much of the data it is unclear at which stage of metastasis ...
Cannabinoids Reduce Extracellular Vesicle Release from HIV-1 Infected Myeloid Cells and Inhibit Viral Transcription
The following supporting information can be downloaded at: https://www.mdpi.com/article/10.3390/cells11040723/s1 , Figure S1: Cell viability analysis of CBD on HIV-1 infected monocyt...
Cannabinoid interventions for improving cachexia outcomes in cancer: a systematic review and meta‐analysis
Low‐quality evidence from both RCTs and NRSIs shows no significant benefits of cannabinoids for weight gain, appetite stimulation, and better quality of life, three important outcome...
Botanically-Derived Δ9-Tetrahydrocannabinol and Cannabidiol, and Their 1:1 Combination, Modulate Toll-like Receptor 3 and 4 Signalling in Immune Cells from People with Multiple Sclerosis
Given the inhibitory effects of THC:CBD on TLR3 signalling to CXCL10 and IFN-β in PBMCs, in addition to evidence linking TLR4 to MS pathogenesis [ 15 16 ], we next set out to determi...
Analysis of Morphological Traits, Cannabinoid Profiles, THCAS Gene Sequences, and Photosynthesis in Wide and Narrow Leaflet High-Cannabidiol Breeding Populations of Medical Cannabis
The measurements were done on five plants per breeding population (N = 5). Photosynthetic Parameters Most photosynthetic parameters differed significantly between breeding populatio...
An Optimized Terpene Profile for a New Medical Cannabis Oil
A total of 2 different extraction procedures were performed according to previous published studies [ 30 32 ] to obtain medical Cannabis oil 1 (MCO-1) and MCO-2 (SIFAP and Calvi meth...
A Low Dose of Pure Cannabidiol Is Sufficient to Stimulate the Cytotoxic Function of CIK Cells without Exerting the Downstream Mediators in Pancreatic Cancer Cells
The uniqueness of CIK cells is their encouraging synergetic effect with cancer associated inhibitors/compounds in preclinical models since cannabinoids have been the subject of inten...
A Cannabinoid 2-Selective Agonist Inhibits Allogeneic Skin Graft Rejection In Vivo
When dissociated spleen cells were placed in culture ex vivo and stimulated with C3HeB/FeJ cells in an MLR, the cells from the O-1966 treated mice were significantly suppressed in th...
The Medicinal Natural Products of Cannabis sativa Linn.: A Review
The applications of plants as medicines predates human history. One notable medicinal plant that has continued to garner attention over the years, and in recent times, is Cannabis s...
The Endocannabinoid System: A Potential Therapeutic Target for Coagulopathies
Blood coagulation disorders or coagulopathies are a group of disorders in which there is a hypercoagulative state leading to excessive abnormal blood clot formation and tissue ischem...
The Effects of Consuming Cannabis Flower for Treatment of Fatigue
Usage sessions included real-time subjective changes in fatigue intensity levels prior to and following Cannabis consumption, Cannabis flower characteristics (labeled phenotype, cann...
The cannabinoid profile and growth of hemp (Cannabis sativa L.) is influenced by tropical daylengths and temperatures, genotype and nitrogen nutrition
Cannabis sativa is a quantitative short-day plant where decreasing daylength (often) regulates flowering initiation (van der Werf et al., 1994). Some studies reported that shorter ph...
The Autism–Psychosis Continuum Conundrum: Exploring the Role of the Endocannabinoid System
Altered transcripts following THC exposure were found in a substantial number of genes linked to autism (80 genes) and intellectual disability (167 genes), with fewer overlapping wit...