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    Effects of standardized Cannabis sativa extract and ionizing radiation in melanoma cells in vitro

    [16] This study was performed to find whether C. sativa extract treatment alone or in combination with single radiation dose (6 Gy) may reduce the cell viability paralleled by increa...


    Different Effects of Cannabis Abuse on Adolescent and Adult Brain

    Taken together, there is a complex interplay between endogenous (agonistic) endocannabinoids, NGF, BDNF, and exogenous (partial agonistic) THC [19, 20] and cannabidiol [20]. This is ...


    Developmental Trajectories of Tobacco/Nicotine and Cannabis Use and Patterns of Product Co-use in Young Adulthood

    Over 1-in-4 young adults ages 18 to 24 report vaping nicotine in the past month.20 -22 Similarly, data from the nationally representative Monitoring the Future (MTF) study showed a m...


    Development of intestinal bioavailability prediction (IBP) and phytochemical relative antioxidant potential prediction (PRAPP) models for optimizing functional food value of Cannabis sativa (hemp)

    Herein two quantitative structure–activity relationship (QSAR) predictive models are presented: the intestinal absorption prediction (IBP) model for predicting compound bioavailabili...


    Commercial Cannabidiol Caution: A New Gold Rush

    Letter to the editorVolume 95, Issue 1p200 Download started Ok Commercial Cannabidiol Caution: A New Gold Rush 1Department of Neurology, Mayo Clinic, Rochester, MN 2Primary Care...


    Chemical Characteristics, Therapeutic Uses, and Legal Aspects of the Cannabinoids of Cannabis sativa: A Review

    Cannabinoid receptors and pain. Pharmacological actions and therapeutic uses of cannabis and cannabinoids. Cannabinoid receptors and pain. Pharmacological actions and therapeutic use...


    Changing the Tone of Clinical Study Design in the Cannabis Industry

    Effect of exogenous cannabinoids on the circadian rhythm Exogenous cannabinoid consumption can distort perception of time due to modulation of the brain’s circadian clock, SCN, whic...


    Changes in Alcohol and Cigarette Consumption in Response to Medical and Recreational Cannabis Legalization: Evidence from U.S. State Tax Receipt Data

    Methods: Dependent variables included per capita consumption of alcohol and cigarettes from all 50 U.S. states, estimated from state tax receipts and maintained by the Centers for D...


    Cannabis use and the sperm epigenome: a budding concern?

    Even in states without legalized cannabis use, CBD is available in enormous numbers of consumer products. Effects of Male Cannabis Use on DNA Methylation: Human Studies To date, onl...


    Cannabis use and nonuse in patients with first-episode psychosis: A systematic review and meta-analysis of studies comparing neurocognitive functioning

    However, few have examined the effects of cannabis use on the cognitive symptoms of psychosis (i.e., neurocognitive functioning) in patients with first-episode psychosis (FEP). The l...


    Cannabis Policy Innovations and the Challenges for EU Coordination in Drug Policy

    In the past decades, Europe has been the site of multiple drug policy innovations and cannabis policy experimentation. Most of the policy reforms in this area are taking place at the...


    ‘Cannabis’ ontologies I: Conceptual issues with Cannabis and cannabinoids terminology

    d. ‘Extracts and tinctures of cannabis’, for which no definition is provided. Only ‘cannabis’, ‘cannabis resin’, and ‘extracts and tinctures of cannabis’ are listed in these Schedul...


    Cannabis hyperemesis syndrome: an update on the pathophysiology and management

    Pharmacology of cannabinoid CB1 and CB2 receptors. Venkatesan T, Levinthal DJ, Li BU, et al. Role of chronic cannabis use: cyclic vomiting syndrome vs cannabinoid hyperemesis syndrom...


    Cannabis as a Gateway Drug for Opioid Use Disorder

    For example, when naloxone and anandamide are co-administered (i.e. in the same NAc microinjections), endocannabinoid “liking” was muted in the presence of naloxone, hedonic response...


    Cannabinoids as an Alternative Option for Conventional Analgesics in Cancer Pain Management: A Pharmacogenomics Perspective

    This review organizes the current knowledge in the context of SNPs associated with opioids and nonopioids and its clinical consequences in pain management and pharmacogenetic targets...


    Cannabidiol for Treating Lennox-Gastaut Syndrome and Dravet Syndrome in Korea

    Find articles by Heung Dong Kim Hoon-Chul Kang 2Division of Pediatric Neurology, Department of Pediatrics, Epilepsy Research Institute, Severance Children’s Hospital, Yonsei Univer...


    Can prescribed medical cannabis use reduce the use of other more harmful drugs?

    Cannabis has been proposed as a useful treatment option in a variety of different physical and mental health conditions, including pain management, multiple sclerosis, epilepsy, depr...


    Associations Between Prenatal Cannabis Exposure and Childhood Outcomes

    Of those with reported data, 87.0% of those in the exposure only before maternal knowledge group (287 of 330) and 92.7% of those in the exposure after maternal knowledge group (140 o...


    Association of early onset of cannabis, cigarette, other drug use and schizophrenia or psychosis

    To address this limitation, Davis et al. (2013) used data derived from the 2004-2005 National Epidemiologic Survey on Alcohol and Related Conditions (NESARC-II) and found that cannab...


    Ambient measurements of monoterpenes near Cannabis cultivation facilities in Denver, Colorado

    By 2018 the industry expanded to 608 medical and recreational Cannabis Cultivation Facilities (CCFs) in Denver County (CDOR, 2018). and its products, and many previous studies have m...


    Adverse events following cannabis for medical use in Tuscany: An analysis of the Italian Phytovigilance database

    DISCUSSION Since 2006 (date of cannabis for medical use approval) until December 2018, the Italian National Institute of Health collected within its Phytovigilance database a total ...


    Acute human exposure assessment to tetrahydrocannabinol (Δ9‐THC)

    Acute dietary exposure assessment methodology11 Acute exposure to total‐Δ9‐THC (Tot‐Δ9‐THC) for consuming days was estimated by matching food consumption data with occurrence data u...


    A Scoping Review on Clinical Trials of Pain Reduction With Cannabis Administration in Adults

    The cannabis products considered for cancer pain were herbal cannabis - inhalation and/or smoked - and cannabis extract and/or oral. J Pain. J Pain. J Pain. Pain.


    A Brief History of Cannabis and the Drug Conventions

    “Drugs”Footnote 1 have been regulated at the international level since 1912, while cannabis has been specifically regulated since 1925. Contemporary local, national, and internationa...


    Thermo-chemical conversion kinetics of cannabinoid acids in hemp (Cannabis sativa L.) using pressurized liquid extraction

    From the kinetics studies the reaction rate constants and activation energies required for the conversion process, as well as those necessary for side reactions and degradation can b...


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