This was followed by the addition of test compounds (5 μM). For HT22 cells, 2,000 cells/well were seeded onto the Seahorse XFe96 plates under normal culture condition as described ab...
The clustering network is calculated by extracting keywords from the articles using the endogenous clustering algorithm in CiteSpace on the reference co-citation network. The top 10 ...
This review summarizes the published studies on CBD and THC–drug interactions, outlines the mechanisms involved, discusses the physiological considerations in pharmacokinetics (PK) a...
A study found that ∆9-THC induces apoptosis and inhibits BC cell proliferation through the activation of CB2 receptor (Zhong et al. 2023). Study found that cannabinoid receptor agoni...
TIME 2 was also not significantly different from TIME 3 (p = 0.124). HADS data was initially analyzed using a two-way repeated measures ANOVA, with factors of TIME (3 levels = TIME 1...
Tetrahydrocannabinolic acid (THCA) diamonds (6aR,10aR)-1-Hydroxy-6,6,9-trimethyl-3-pentyl-6a,7,8,10a-tetrahydro-6H-benzo[c]chromene-2-carboxylic acid. It is also reported that even ...
For both brain regions (i.e., nucleus accumbens and infralimbic cortex), images were sampled from 3-4 sagittal sections, spaced 300 μm apart, per animal. Figure 2 3.2 No behavioral ...
These unique features contribute to the growing numbers of recreational drug users who have used SCs [ 4 5 ]. The Psychoactive Ingredients of Synthetic Cannabinoid Products 22,69, O...
It is a severe abnormal pain syndrome, generally characterized by spontaneous pain (pain in the absence of any stimulus). The findings of a 2005 observational study suggest that cann...
Bioluminescence resonance energy transfer (BRET) assay For BRET assay, HEK-293T cells were transiently cotransfected with a constant amount of cDNA encoding for GluN1-RLuc (0.25 μg)...
A total of 21 samples were obtained from 24 patients. In order to measure adiponectin secretion in LPS-stimulated mature adipocytes, as well as the effect of SR141716A on these cells...
The therapeutic potential of Cannabis sativa, particularly its bioactive components like cannabinoids and terpenes, has garnered substantial attention in contemporary research. Limon...
Interestingly, work done by our group has shown that treatment of DIO mice with the CB1 antagonist SR141716A reverses obesity and is associated with a decrease in ATM-dependent infla...
Fowler, University of California Smoke and Tobacco Free Fellowship (https://www.ucop.edu/risk-services/loss-prevention-control/uc-smoke-tobacco-free.html) to A.N. Further, given that...
Nowadays cardiovascular diseases (CVDs) are the major causes for the reduction of the quality of life. The endocannabinoid system is an attractive therapeutic target for the treatmen...
The results in the THC-dominant group in the present study are similar to findings from our prior study18, in which individuals using 70% or 90% THC concentrate products demonstrated...
Therefore, we aimed at evaluating the safety and effectiveness of cannabinoids used by routes other than oral or inhalation for neuropathic pain compared to placebo or other medicati...
Behavioral studies with the use of cannabinoids in the zebrafish model. Use of cannabinoids in the treatment of disease models induced in zebrafish. Though literature data does not m...
Increased expression of the components of the ECS and elevated levels of endocannabinoids increase food intake and produce hunger due to the activation of orexigen pathways in the hy...
It involves a combination of cannabinoid receptors, endogenous cannabinoids (endocannabinoids), and enzymes responsible for the synthesis and degradation of endocannabinoids. The fir...
There is a definite need for more RCT studies, especially in severe mood disorders such as MDD and BD, where there is a lack of such studies. CBD-enriched preparations appear to show...
After tissue infiltration, macrophages contribute to innate immune responses through antigen presentation, the production of several cytokines, such as IL-1, IL-6, and TNF-α, and the...
The expression of THCAS in these hosts was very low, although it opened the door to the possibility of biotechnological Δ-THCA production by means of biotechnological platforms.was i...
Although there is a lack of strong evidence on the efficacy of cannabinoids for the treatment of RA and other rheumatic diseases, cannabinoids have been seen as a potential therapy d...
Endocannabinoids that are produced excessively in sepsis are potential factors leading to immune dysfunction, because they suppress immune cell function by binding to G-protein-coupl...