1), which has been examined as a potential anticancer therapeutic (Mechoulam et al. 1968; Kogan et al. 2004; Kogan et al. 2007a; Kogan et al. 2007b). HU-331 has been shown to be acti...
Moreover, the replacement of an alkyl chain to a phenyl containing linker on the hapten of vaccine 7 caused a threefold affinity enhancement compared to vaccine 6, which is an effect...
Phytocannabinoid concentrations and corresponding receptor potencies of cannabis oil samples. Using a similar strategy, we correlated the CB1 and CB2 receptor potencies of the medica...
To the best of our knowledge, this is the first study that seeks to investigate if infant genetic susceptibility interacts with the quality of parental caregiving in predicting attac...
Moreover, terpineol showed an antidepressant-like effect in the preventive treatment that was blocked by a nonselective dopaminergic receptor antagonist (haloperidol), a selective do...
Co-metabolism of AEA with NADA or NA5HT We next determined the co-substrate kinetics of AEA with the eVDs to determine if we can explain the observed effects of AEA on BV2-mediated ...
Diversity in CBCAS Sequences Specific primers were designed following a search for the “fiber-type THCAS” reference sequence, AB212830 [8], in the genome assemblies available on NCB...
DNA sequencing and mapping Bulked DNA from each chemotypically extreme pool was subject to whole genome sequencing with Illumina sequencing-by-synthesis technology, generating 250,9...
by Mary K. Swinton , Erin E. Sundermann , Lauren Pedersen , Jacques D. Nguyen , David J. Grelotti , Michael A. Taffe , Jennifer E. Iudicello and Jerel Adam Fields * ...
Intestinal disequilibrium leads to inflammatory bowel disease (IBD), and chronic inflammation predisposes to oncogenesis. Antigen-presenting dendritic cells (DCs) and macrophages can...
This review addresses acidic and neutral cannabinoid structural pairs, when and where acidic cannabinoid decarboxylation occurs, the kinetics and mechanism of the decarboxylation rea...
The endocannabinoid system (ECS), a conserved physiological system emerged as a novel pharmacological target for its significant role and potential therapeutic benefits ranging from ...
Conformational differences in specific transmembrane helices were investigated using the simulated annealing/Monte Carlo (MC) conformational analysis method of conformational memorie...
Although it remains uncertain which specific biological (i.e., sex) and socio-cultural (i.e., gender) factors affect cannabis use in humans, animal studies strongly suggest the invol...
The membranes were incubated for 90 min at 30°C with the radioligand and different concentrations of the different derivatives. Anti-Inflammatory Effect on Human Monocytes To test t...
Further binding analysis for the three compounds 7, 15, and 17, exhibiting ≥50% displacement at the CB1 receptor when tested at 10 μM, revealed that the binding curves of the compoun...
In the hearts of subjects over 50 (Fig. Computer image analysis confirmed visually perceived age-related changes in the intensity of the immunohistochemical reaction against CB1, CB2...
A major caveat is that most studies investigated effects using male progeny only. Specifically, we found that prenatal cannabinoid exposure (PCE) reduces social interactions in males...
However, little research has been conducted regarding the response of yield and cannabinoid levels/composition to the application of plant-growth promoting rhizobacteria (PGPR), alth...
To this end, in this study we evaluated all the downstream signaling of CB2 and developed a method for quantifying CB2R activation in primary mouse and human blood cells based on the...
Emerging evidence has shown the protective effects of PPAR-γ against diabetic kidney disease [26,27]; our quantitative RT-PCR and immunohistochemical studies ( and ) showed that over...
Microglia 2.1. Cell. Cell 2008, 132, 631–644. Cell 2010, 7, 483–495. Cell 2013, 155, 1596–1609.
Albeit these protective effects, however, recent data are implicating cannabinoid receptors in cell death in the retina, both in the early developing (Freitas et al., 2019) and disea...
Previously, we demonstrated a significant reduction in CB1 receptor gene expression levels in cancer tissue compared to normal surrounding mucosa of patients with colorectal cancer (...
Cluster analysis of alkyl cannabinoid fractions was performed to provide insight into the categorization and genetic regulation of alkyl cannabinoid chemotypes in Cannabis. FIGURE 2 ...