Therapeutic properties of multi-cannabinoid treatment strategies for Alzheimer’s disease
Steiner-Lim | Genevieve Z
for mice). Treatment effects of cannabinoid combinations and cannabis extracts in Alzheimer’s disease Research suggests that cannabinoid treatments involving a combination of THC and CBD and other cannabinoids can produce greater therapeutic outcomes and less adverse effects than treatment with purified cannabinoid isolates. Chronic treatment of 6-month-old male APP/PS1 mice with either a CBD-rich (64.8% CBD, 2.3% THC), THC-rich (67.1% THC, 0.3% CBD), or 1:1 CBD:THC combination extract (all 0.75 mg/kg for each cannabinoid) reversed object recognition memory deficits of AD transgenic mice. Importantly, further research is required including clinical studies for multi-cannabinoid combination therapy in AD. Conflict of interest GZS and TK have received funding from medicinal cannabis companies to conduct research on medicinal cannabis products, outside of this study.