The Interplay between Cannabinoid Receptors and Microglia in the Pathophysiology of Alzheimer’s Disease
Rebecca Ferrisi | Francesca Gado | Caterina Ricardi | Beatrice Polini | Clementina Manera | Grazia Chiellini
This cannabinoid displayed significant therapeutic potential for the treatment of neurodegenerative diseases, such as AD. In 2018, Navarro and co-workers investigated the expression and signaling properties of CBRs both in resting and in LPS/IFN-γ-activated microglia and found an increased expression of CB1-CB2 receptor heteromers (CB1R-CB1RHets) in activated microglia, which also resulted in them being highly responsive to cannabinoids. [Google Scholar] [CrossRef] Stella, N. Endocannabinoid Signaling in Microglial Cells. Stimulation of Cannabinoid Receptor 2 (CB2) Suppresses Microglial Activation. ; et al. Cannabinoid CB2 Receptors Modulate Microglia Function and Amyloid Dynamics in a Mouse Model of Alzheimer’s Disease.
Tags:
- Microglia
- Cannabinoid receptor 2
- Neuroinflammation
- Cannabinoid receptor 1
- Functional selectivity
- Endocannabinoid system
- Interleukin 10
- Macrophage polarization
- Neurodegenerative disease
- Allosteric regulation
- Inflammation
- Amyloid beta
- Anandamide
- 2-Arachidonoylglycerol
- Cell signaling
- Tumor necrosis factor
- Kinase
- TREM2
- Cell biology
- Cell communication
- Signal transduction
- Biology
- Neurochemistry
- Biochemistry