Saturated Cannabinoids: Update on Synthesis Strategies and Biological Studies of These Emerging Cannabinoid Analogs
Maite L. Docampo-Palacios | Giovanni A. Ramirez | Tesfay T. Tesfatsion | Alex Okhovat | Monica Pittiglio | Kyle P. Ray | Westley Cruces | Docampo-Palacios | Maite L | Giovanni A
Since its discovery in 1940, through catalytic hydrogenation of THC and cannabinoid derivatives, hydrogenated cannabinoids have been synthesized; only H4CBD and HHC have been of interest as they are the hydrogenated scaffolds of THC and CBD [8]. 3-chlorobenzoperoxoic acid was used for the oxidation reaction to obtain compounds 1 and 7 with a 56% and 40% yield, respectively, from the last two steps. Hydrogenation reaction of HHCA-27. (A) Compound 166 against the CB1 receptor; (B) compound 166 against the CB2 receptor [103]. Cannabinoids.
Tags:
- Cannabinoid
- Ligand (biochemistry)
- Cannabinoid receptor 2
- Endocannabinoid system
- Cannabidiol
- Anandamide
- Fatty-acid amide hydrolase 1
- Tetrahydrocannabinol
- Hexahydrocannabinol
- Diels–Alder reaction
- Cannabinoid receptor 1
- Baeyer–Villiger oxidation
- Receptor (biochemistry)
- Cannabinoid receptor
- Organic chemistry
- Concepts in chemistry
- Chemistry