Phytochemical Analysis of the Methanolic Extract and Essential Oil from Leaves of Industrial Hemp Futura 75 Cultivar: Isolation of a New Cannabinoid Derivative and Biological Profile Using Computation
De Vita, Finamore, Chini, Maria Giovanna, Saviano, De Felice, De Marino, Lauro, Casapullo, Fantasma
Cannabis sativa L. has a wide range of therapeutic applications against several diseases, and many review articles have detailed its chemistry [ C. sativa L. in addition to Δ9-THC include CBD, tetrahydrocannabivarin (THCV), cannabinol (CBN), cannabigerol (CBG), and cannabichromene (CBC) [ L. has a wide range of therapeutic applications against several diseases, and many review articles have detailed its chemistry [ 14 ], the structure–activity relationship [ 15 16 ], and the complex biosynthesis of phytocannabinoids [ 6 17 ]. Compared to other cultivars, Futura 75 is a late crop, thus being more suitable for cultivation in mountainous regions [ Futura 75 ” [ Futura 75 [ The interest in this plant has increased following the actual international trends toward use for therapeutic purposes, and monoecious varieties have been selected in modern times to reduce agronomic problems, although a small percentage of monoecious plants can naturally occur. In the Abruzzo and Marche regions (central Italy), hemp cultivation is the object of renewed interest, and therefore the selection of Futura 75 was made considering the local climatic and soil characteristics. When Futura 75 variety is grown for seed and fiber production, the residual green parts, leaves, and stems are considered waste material. Futura 75 , and the inflorescences, leaves, and seeds are commercially used for food preparations such as herbal teas, oil, or cosmetic purposes.