Perturbation of 3D nuclear architecture, epigenomic dysregulation and aging, and cannabinoid synaptopathy reconfigures conceptualization of cannabinoid pathophysiology: part 1–aging and epigenomics
Albert Stuart Reece | Gary Kenneth Hulse
Table 1 N Group Disorder Genes identified in the Schrott database Genes implicated % Genes implicated in Schrott Reference 1Brain disordersSchizophrenia59768587.10%Trubetskoy V. Nature 2022; 604(7906): 502–5082Congenital anomaliesOocytic Zar1 activation16220877.88%Cheng S, Science, 2022; 378 (6617)3Congenital anomaliesSperm2,9744,93060.34%Chen Y, Cell Res. Epigenetic effects of cannabis exposure. Cell. Cells. Aging Cell.
Tags:
- Cellular differentiation
- DNA repair
- Epigenomics
- Transcription (biology)
- Enhancer (genetics)
- Promoter (genetics)
- Histone
- Endocannabinoid system
- Super-enhancer
- Chromatin
- Birth defect
- Nucleosome
- Atresia
- Epigenetics
- DNA
- CTCF
- Synapse
- Branched-chain amino acid
- Cell signaling
- N6-Methyladenosine
- DNA methylation
- RAD51
- Cannabinoid
- Gene expression
- T helper cell
- Gene
- Congenital heart defect
- Carcinogenesis
- Mitochondrion
- Biochemistry
- Genetics
- Biotechnology
- Cellular processes
- Biology
- Biological processes
- Life sciences
- Health sciences
- Molecular biology
- Cell biology