Molecular Advances on Cannabinoid and Endocannabinoid Research
Rosaria Meccariello
Interestingly, SYNGAP1 is a known biomarker of neurodevelopmental disorders [32], and the authors demonstrate that the protein is also increased in the prefrontal cortex of Δ9-THC exposed rats, thus suggesting that SYNGAP1 may be the link between adolescence cannabis use and adverse neuropsychiatric outcomes. Taken together, this Special Issue of IJMS provides new insights into the involvement of cannabinoids and endocannabinoids in the maintenance of health status and the onset of disease, suggesting new actors in the cannabinoid world, and providing new molecular mechanisms, diagnostic markers and targets in cancer, drug abuse and addiction, aging or pain management. [Google Scholar] [CrossRef] World Drug Report 2021. [Google Scholar] [CrossRef] [PubMed] Mazzeo, F.; Meccariello, R.; Guatteo, E. Molecular and Epigenetic Aspects of Opioid Receptors in Drug Addiction and Pain Management in Sport. [Google Scholar] [CrossRef] Spanagel, R. Cannabinoids and the endocannabinoid system in reward processing and addiction: From mechanisms to interventions.