MicroRNA-29a Attenuates Diabetic Glomerular Injury through Modulating Cannabinoid Receptor 1 Signaling
Chun-Wu Tung | Cheng Ho | Yung-Chien Hsu | Shun-Chen Huang | Ya-Hsueh Shih | Chun-Liang Lin | Chun-Wu | Yung-Chien | Shun-Chen | Ya-Hsueh
Emerging evidence has shown the protective effects of PPAR-γ against diabetic kidney disease [26,27]; our quantitative RT-PCR and immunohistochemical studies ( and ) showed that overexpression of miR-29a significantly reversed the attenuated PPAR-γ expression in diabetic mice. Induction of proteinuria by cannabinoid receptors 1 signaling activation in CB1 transgenic mice. Diabetes 2014, 63, 2120–2131. Share and Cite MDPI and ACS Style Tung, C.-W.; Ho, C.; Hsu, Y.-C.; Huang, S.-C.; Shih, Y.-H.; Lin, C.-L. MicroRNA-29a Attenuates Diabetic Glomerular Injury through Modulating Cannabinoid Receptor 1 Signaling. Molecules 2019, 24, 264. https://doi.org/10.3390/molecules24020264 AMA Style Tung C-W, Ho C, Hsu Y-C, Huang S-C, Shih Y-H, Lin C-L. MicroRNA-29a Attenuates Diabetic Glomerular Injury through Modulating Cannabinoid Receptor 1 Signaling.
Tags:
- Cannabinoid receptor 1
- Transcription factor Jun
- Cannabinoid receptor 2
- MicroRNA
- Tumor necrosis factor
- Gene expression
- Glomerulus (kidney)
- Diabetic nephropathy
- Downregulation and upregulation
- Interleukin 6
- Kidney disease
- Kidney
- Mesangial cell
- Real-time polymerase chain reaction
- Extracellular matrix
- Life sciences
- Cell biology
- Biochemistry
- Biotechnology
- Molecular biology
- Biology