Inflammation and cancer: friend or foe?
Turizo-Smith, Andrés David, Córdoba-Hernandez, Mejía-Guarnizo, Lidy Vannessa, Monroy-Camacho, Paula Stefany, Rodríguez-García, Josefa Antonia
Figure 1 Tumor-associated macrophages (TAMs), which represent up to 50% of the tumor mass within the TME, play a significant role in promoting cell proliferation, suppressing the antitumor immune response, and enhancing immune evasion and metastasis. It is crucial to note that therapy-induced tumor cell death promotes the production of growth factors and cytokines, including WNT, EGF, TNF, IL-17, and IL-6, by cells in the TME to promote the survival of remaining tumor cells and play a role in fostering therapy resistance (Greten and Grivennikov, 2019). 6 Therapeutic approaches in cancer Therapeutic strategies targeting cancer-associated inflammation include the exploration of anti-inflammatory drugs, particularly non-steroidal anti-inflammatory drugs (NSAIDs), which function by inhibiting COX enzymes. This leads to reduced levels of IL-1β. These findings support the potential use of cannabinoids as anti-inflammatory agents for various chronic inflammatory diseases and provide insights into their mechanisms of action.
Tags:
- Tumor microenvironment
- Inflammation
- Tumor-associated macrophage
- Macrophage
- NF-B
- Tumor necrosis factor
- Cannabinol
- Immune system
- Interleukin 6
- Cancer
- Cytokine
- Carcinogenesis
- Inflammatory cytokine
- Transforming growth factor beta
- Apoptosis
- Cannabinoid receptor 2
- Angiogenesis
- Endocannabinoid system
- Cannabinoid
- Anti-inflammatory
- Cellular processes
- Cell signaling
- Biochemistry
- Clinical medicine
- Biology
- Cell biology
- Medical specialties