Flipping the GPCR Switch: Structure-Based Development of Selective Cannabinoid Receptor 2 Inverse Agonists
Miroslav Kosar | Roman C. Sarott | David A. Sykes | Alexander E. G. Viray | Rosa Maria Vitale | Nataša Tomašević | Xiaoting Li | Rudolf L. Z. Ganzoni | Bilal Kicin | Lisa Reichert
[PubMed] [CrossRef] [Google Scholar] Copeland R. A. [PubMed] [CrossRef] [Google Scholar] [Ref list] Copeland R. A. [PubMed] [CrossRef] [Google Scholar] [Ref list] Olajide O. [PMC free article] [PubMed] [CrossRef] [Google Scholar] [Ref list] Filipek S. Molecular switches in GPCRs. [PubMed] [CrossRef] [Google Scholar] [Ref list]
Tags:
- Cannabinoid receptor 2
- Ligand (biochemistry)
- MAPK/ERK pathway
- Functional selectivity
- Time-resolved fluorescence energy transfer
- Drug design
- Agonist
- Extracellular signal-regulated kinases
- Cell signaling
- Receptor antagonist
- Cyclic adenosine monophosphate
- G protein-coupled receptor
- Arrestin
- EC50
- Docking (molecular)
- G protein
- Receptor (biochemistry)
- Pharmacology
- Förster resonance energy transfer
- Protein structure
- Cannabinoid receptor 1
- Biochemistry
- Cell biology
- Biology
- Neurochemistry
- Cell communication