Exploring the Therapeutic Potential of Cannabinoid Receptor Antagonists in Inflammation, Diabetes Mellitus, and Obesity
Alexandru Vasincu | Răzvan-Nicolae Rusu | Daniela-Carmen Ababei | Monica Neamțu | Oana Dana Arcan | Ioana Macadan | Sorin Beșchea Chiriac | Walther Bild | Veronica Bild | Răzvan-Nicolae
These processes include neuronal development, food intake, energy balance, and the modulation of the immune system. Immune signaling and inflammation are also regulated by CB2Rs. In the treatment of inflammatory diseases, the administration of CB2R agonists may have an anti-inflammatory effect. Cannabinoid Receptor Modulators in Inflammation and Immune Processes By interacting with CBRs on cell membranes, cannabinoids have also been shown to modulate the immune system, being considered a potential therapeutic target for peripheral and central inflammatory diseases [73,83]. CB2Rs are known to be involved in the modulation of immune responses but are also involved in carbohydrate metabolism and body weight modulation.
Tags:
- Cannabinoid receptor 2
- Cannabinoid receptor 1
- MAPK/ERK pathway
- Diabetes
- Insulin resistance
- Endocannabinoid system
- G protein-coupled receptor
- Extracellular signal-regulated kinases
- Adiponectin
- Beta cell
- Cell signaling
- Inflammation
- Metabolic syndrome
- Type 1 diabetes
- Insulin
- Mitogen-activated protein kinase
- Kinase
- Adipocyte
- Adipose tissue
- Fatty-acid amide hydrolase 1
- Type 2 diabetes
- Tumor necrosis factor
- Obesity
- Signal transduction
- Atheroma
- Diabetic nephropathy
- Biochemical cascade
- Complications of diabetes
- Anandamide
- Cannabinoid
- Cyclic adenosine monophosphate
- Non-communicable disease
- Hunger (physiology)
- Neuroinflammation
- Leptin
- Neurochemistry
- Medical specialties
- Cell biology
- Biochemistry