Effects of short-term cannabidiol treatment on response to social stress in subjects at clinical high risk of developing psychosis

King's College London

Cannabidiol (CBD) has antipsychotic and anxiolytic effects. Across the three participant groups, there was a significant F(1,54) = 9.46, p = .003 linear decrease in cortisol reactivity, such that the change in cortisol (cortisol at time 0 min relative to baseline; − 60 min) associated with experimental stress exposure was greatest in HC controls and least in CHR-P patients, with CHR-CBD patients exhibiting an intermediate response (Fig. Collectively, these findings suggest that CHR participants under placebo displayed abnormal neuroendocrine and psychological responses to experimental stress compared with HC participants, and that 7-day treatment with CBD may potentially help partially attenuate these altered responses to experimental stress in CHR participants. [PubMed] [CrossRef] [Google Scholar] [Ref list] Campos AC, Guimarães FS. [PubMed] [CrossRef] [Google Scholar] [Ref list]

https://www.ncbi.nlm.nih.gov/pmc/articles/7113209

Tags:

Trier social stress test

Stress (biology)

Fatty-acid amide hydrolase 1

Psychosis

Missing data

Institute of Psychiatry

Psychology and Neuroscience

Health