Effects of Cannabidiol on Locomotor Activity
Calapai, Cardia, Di Mauro, Trimarchi, Ammendolia, Mannucci, Fabrizio Calapai, Luigi Cardia, Gioacchino Calapai, Debora Di Mauro
The results showed that CBD administration did not influence motor activity evaluated by accelerating rotarod tests, while it reduced locomotor activity in the OF [ 42 ]. In summary, these findings show that long-term CBD treatment did not produce side effects regarding motor activity or memory and did not cause anxiety behavior [ 42 ]. However, the results showed that acute CBD reduced anxiety induced by EPM, but it had no impact on locomotion or anxiety-related parameters of Fmr1mice in the OF experiments [ Fmr1 -deficient and WT mice, without any effect on locomotor activity, social, or cognitive performance. In this study, CBD administration resulted in a further reduction in anxiety-like behavior in both-deficient and WT mice, without any effect on locomotor activity, social, or cognitive performance. CBD (5 mg/kg) or a vehicle were investigated in 12-month-old APPSwe/PS1ΔE9 (APP/PS1) transgenic female mice and their control, commencing the treatment three weeks prior to the assessment of behavior consisting of sectors including anxiety, exploration, locomotion, motor functions, cognition, and sensorimotor gating.