Cannabinoid and Opioid Receptor Affinity and Modulation of Cancer-Related Signaling Pathways of Machaeriols and Machaeridiols from Machaerium Pers.

by Ilias Muhammad 1,* , Mohammad A. Ibrahim 1 , Mallika Kumarihamy 1,† , Janet A. Lambert 1,‡ , Jin Zhang 1 , Marwa H. Mohammad 1,§, Shabana I. Khan 1,2 , David S. Pasco 1,2 and Premalatha Balachandran 1,* 1 National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, The University of Mississippi, University, MS 38677, USA 2 Department of BioMolecular Sciences, Division of Pharmacognosy, School of Pharmacy, The University of Mississippi, University, MS 38677, USA * Authors to whom correspondence should be addressed. Molecules 2023, 28(10), 4162; https://doi.org/10.3390/molecules28104162 Submission received: 14 April 2023 / Revised: 10 May 2023 / Accepted: 15 May 2023 / Published: 18 May 2023 (This article belongs to the Special Issue Plant Bioactive Compounds: Extraction, Identification and Biological Activities) Abstract Machaeriols and machaeridiols are unique hexahydrodibenzopyran-type aralkyl phytocannabinoids isolated from Machaerium Pers. Due to recent reports on the anticancer potential of the endocannabinoid system, compounds 1–7 were tested against a battery of luciferase reporter gene vectors that assess the activity of many cancer-related signaling pathways, including Stat3, Smad2/3, AP-1, NF-κB, E2F, Myc, Ets, Notch, FoxO, Wnt, Hedgehog and pTK in HeLa and T98G glioblastoma cells. This appears to be the first comprehensive report on cannabinoid and opioid receptor affinities, cytotoxic activities and the modulation of cancer-related signaling pathways of natural compounds for machaeriol A–D (1–4) and machaeridiol A–C (5–7). Molecules 2023, 28, 4162. https://doi.org/10.3390/molecules28104162 AMA Style Muhammad I, Ibrahim MA, Kumarihamy M, Lambert JA, Zhang J, Mohammad MH, Khan SI, Pasco DS, Balachandran P. Cannabinoid and Opioid Receptor Affinity and Modulation of Cancer-Related Signaling Pathways of Machaeriols and Machaeridiols from Machaerium Pers.

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