Antitumor Cannabinoid Chemotypes: Structural Insights
Non-CB1R, non-CB2R targets related to the endocannabinoid system have also been reported to be involved in the anticancer action of cannabinoids. Cannabinoids with Anticancer Potential Molecules that modulate the endocannabinoid system are considered cannabinoids. CB2R activation has been reported to be involved in the antiproliferative effect of JWH-015 in different cancer cells, such as PC-3 prostate cancer cells (Olea-Herrero et al., 2009). Naphthyridine and Naphthalene 1,8-Naphthyridin-2-ones, CB2R agonists, have been shown to be, in general, more active against prostate carcinoma cells (DU-145 cell line) than MCF-7 breast carcinoma cells, gastric adenocarcinoma cells, and glioblastoma cells (Manera et al., 2012). Therefore, cannabinoid combinations may provide an improved antiproliferative strategy for cancer management.