A Crosstalk between the Cannabinoid Receptors and Nociceptin Receptors in Colitis—Clinical Implications

Wołyniak, Małecka-Wojciesko, Zielińska, Fabisiak, Maria Wołyniak, Ewa Małecka-Wojciesko, Marta Zielińska, Adam Fabisiak

In addition to interacting with cannabinoid receptors 1 and 2 (CB1 and CB2, respectively), the endogenous cannabinoid system (ECS) communicates with other receptor families such as opioid receptors [ 2 ]. Little is known on the potential crosstalk between CB receptors and NOP receptors. Among them, the most significant is the withdrawal effect, which decrease after the activation of NOP receptors in the CNS. In terms of nociceptin, in a study concerning an effect of postsynaptic opioid and cannabinoid receptors on calcium currents in a neonatal rat nucleus of the solitary tract, it was concluded that N and P/Q type calcium channels were inhibited by both DAMGO and nociceptin, while L-type channels were inhibited by WIN55122.7. Both effects were blocked by a selective CB1 antagonist, AM251, demonstrating that Δ9-THC is able to affect NOP receptors and that the mechanism is most likely activated by the stimulation of the CB1 receptor.

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