Focus on the Endogenous Cannabinoid System in Migraine
In a case study by Prof Ethan Russo, a leading authority on the subject, 80% of migraineurs benefit from the ingestion of cannabis, often with complete resolution of symptoms.4 Retu...
Effect of interaction between acute administration of morphine and cannabinoid compounds on spontaneous excitatory and inhibitory postsynaptic currents of magnocellular neurons of supraoptic nucleus
Thus, the results of co-administration of morphine and cannabinoid compounds in this study showed that cannabinoids could modulate the morphine effects on spontaneous synaptic curren...
Discovery of High-Affinity Cannabinoid Receptors Ligands through a 3D-QSAR Ushered by Scaffold-Hopping Analysis
Introduction The receptors of the endocannabinoid system are the cannabinoid receptors. The 3D visualizations of the QSAR models are shown in and , where the 3D-QSAR coefficients fo...
Culture and cannabinoid receptor gene polymorphism interact to influence the perception of happiness
Furthermore, CNR1 polymorphism has been associated with happiness [7]. A previous study indicated that both the subjective happiness level and situation-specific happiness were highe...
Clinical characteristics of synthetic cannabinoid-induced psychosis in relation to schizophrenia: a single-center cross-sectional analysis of concurrently hospitalized patients
Hence, adolescent cannabinoid exposure is considered likely to be a risk factor for developing psychosis symptoms in adulthood.45 Hence, our findings support the evidence regarding ...
CB2 Cannabinoid Receptor As Potential Target against Alzheimer’s Disease
TABLE 1 TABLE 2 Anti-Inflammatory Effects of CB2 Receptor Activity Inflammation is common in most neurodegenerative diseases including AD, and it may contribute to progressive neu...
Case Series of Synthetic Cannabinoid Intoxication from One Toxicology Center
Although he developed aspiration pneumonia, he was treated and discharged uneventfully on hospital day (HD) six. The patient was found unresponsive; she was endotracheally intubated ...
Cannabinoid Type 2 (CB2) Receptors Activation Protects against Oxidative Stress and Neuroinflammation Associated Dopaminergic Neurodegeneration in Rotenone Model of Parkinson’s Disease
In the present study, we have investigated the neuroprotective effects of BCP in ROT induced rat model of PD, via CB2 receptor-dependent mechanism by using a selective CB2 receptor a...
Cannabinoid Receptors and the Endocannabinoid System: Signaling and Function in the Central Nervous System
Not long after that, another cannabinoid receptor (CBR) was identified and cloned, later termed as the cannabinoid receptor 2 (CB2R) [8]. Cannabinoid receptors and their ligands: Bey...
Cannabinoid receptor type-1: breaking the dogmas
Interestingly, recent findings have shown how CB1 receptors can modulate microglia activation, suggesting its presence in this cell type49. However, further studies and more direct, ...
Cannabinoid Modulation of the Stressed Hippocampus
Stress Induces Changes in Cannabinoid-Mediated Hippocampal Neuroplasticity Probably reflecting its role in several brain functions such as learning, memory and affective processing,...
Cannabinoid CB2 Receptor Gene and Environmental Interaction in the Development of Psychiatric Disorders
Reduced Fkbp5 and Nr3c1 gene expressions in the brain of the Cnr2 heterozygote knockout mice in comparison to wild type mice indicated the developed anxiety-like behavior by Poly I:C...
Cannabinoid CB1 Receptors Are Localized in Striated Muscle Mitochondria and Regulate Mitochondrial Respiration
Mitochondrial Isolation from Heart and Mitochondrial Respiration Mitochondria were isolated from the heart of the mice by differential centrifugation. Mitochondrial respiration was ...
Cannabigerol Action at Cannabinoid CB1 and CB2 Receptors and at CB1–CB2 Heteroreceptor Complexes
Competition Binding Experiments [3H]-CP-55940 competition binding experiments were performed incubating 0.3 nM of radioligand and different concentrations of the tested compounds wi...
Cannabidiol, among Other Cannabinoid Drugs, Modulates Prepulse Inhibition of Startle in the SHR Animal Model: Implications for Schizophrenia Pharmacotherapy
The absence of AM 404 effects on the PPI of SHRs suggest that increasing anandamide levels is not sufficient to restore SHRs’ PPI impairment. The results, thus, point to an antipsych...
The Cannabinoid Receptor CB1 Interacts with the WAVE1 Complex and Plays a Role in Actin Dynamics and Structural Plasticity in Neurons
Importantly, we demonstrate that cannabinoids structurally remodel synaptic spines by regulating the activity levels of WAVE1 and report a novel function for WAVE1 in mediating infla...
Interaction between Cannabinoid System and Toll-Like Receptors Controls Inflammation
Cannabinoid receptors and their ligands: Beyond CB1 and CB2, Pharmacological Reviews. 40 Howlett A. C., Cannabinoid receptor signaling, Handbook of Experimental Pharmacology. 98 Nong...
Impaired Ethanol-Induced Sensitization and Decreased Cannabinoid Receptor-1 in a Model of Posttraumatic Stress Disorder
Cannabinoid receptor-1 (CB1) is sensitive to the effects of ethanol (EtOH) and traumatic stress, and is a critical regulator of striatal plasticity. The impaired behavioral response ...
First-Episode of Synthetic Cannabinoid-Induced Psychosis in a Young Adult, Successfully Managed with Hospitalization and Risperidone
Synthetic cannabinoids mainly interact with cannabinoid receptors (CB) [2–5, 7, 10]. Seizures are less common but have also been reported [3]. At the next appointment, 2 weeks after ...
Systematic review of drug-drug interactions of delta-9-tetrahydrocannabinol, cannabidiol, and Cannabis
With this expanding use of cannabis and cannabinoids, clinicians, researchers, and patients require a better understanding of the potential for cannabinoids to interact with other me...
Phytocannabinoids: Exploring Pharmacological Profiles and Their Impact on Therapeutical Use
CBD has antioxidant effects, which may contribute to its neuroprotective effects and overall health benefits [22]. Other Phytocannabinoids 2.4.1. In particular, the anti-inflammator...
Partially substituting alfalfa hay with hemp forage in the diet of goats improved feed efficiency, ruminal fermentation pattern and microbial profiles
This study investigated the effects of partial substitution of alfalfa hay (AH) with hemp forage (HF) in growing goat diets on growth performance, carcass traits, ruminal fermentatio...
Non-destructive assessment of cannabis quality during drying process using hyperspectral imaging and machine learning
According to Chen et al. (2021), hot-air drying increased CBDA conversion rate and decreased drying time as the temperature increased from 40°C to 90°C. Figure 3 Figure 4 3.3 Chang...
Medicinal Cannabis (MedCan 3): a randomised, multicentre, double-blind, placebo-controlled trial to assess THC/CBD (1:20) to relieve symptom burden in patients with cancer—a study protocol for a rando
Secondary objectives include (a) ascertaining the median dose of 1:20 THC/CBD formulation achieved when patients are asked to titrate to effect or tolerance within a pre-specified ra...
Inflammation and cancer: friend or foe?
Figure 1 Tumor-associated macrophages (TAMs), which represent up to 50% of the tumor mass within the TME, play a significant role in promoting cell proliferation, suppressing the an...