Clinical and experimental data have demonstrated that aging is accompanied by histopathological changes in the heart such as cardiomyocyte apoptosis, cardiac muscle cell hypertrophy ...
have been shown to be expressed on human epidermal keratinocytes [45,91,92,95,111,133], and the functional activity of the putative EMT was also demonstrated on these cells [170]. Fi...
1 and 2 were characterised by NMR spectroscopy and HRMS (data not shown), and sample purity of test compounds was 97.3 and 100%, respectively. 7, 15, and 16 were characterised by NMR...
FIGURE 1 Since very few works in the literature describe the fragmentation mechanism of the most common cannabinoids using an electrospray ionization source in both positive and neg...
FIGURE 1 FIGURE 2 FIGURE 3 Many endogenous and exogeneous compounds activate receptors found in the TRP superfamily. In addition to these pungent compounds, the six TRP channels t...
The release of cannabinoids from a microneedle formulation that is administered transdermally has been reported by Brooke [101], while a patent by Weimann has more recently focused o...
One of these signals has been shown to come through the action of endocannabinoids (eCBs), mainly via activation of cannabinoid receptors type 1 and 2 (CB1R and CB2R). Regulators of ...
The specific goals of this simulation were to: (1) observe if the interactions between the receptor, the orthosteric antagonist and CBD, as proposed by the docking studies persisted ...
BDNF Crosstalk With Cannabinoid Receptors Modulates Neuronal Differentiation at SVZ To evaluate the effects on SVZ neuronal differentiation, SVZ cells were treated with the test dru...
Non-CB1R, non-CB2R targets related to the endocannabinoid system have also been reported to be involved in the anticancer action of cannabinoids. Cannabinoids with Anticancer Potenti...
When GC-MS analysis of a VEA standard was performed, there were retention time and mass spectral matches for the component in the vaporizer fluid to that of the VEA analytical standa...
Therefore, together with previous data [28], we have further provided evidence to support that activation CB1 may be a good target for corneal neuropathic pain management by direct m...
Improved production of cannabinoids With our designed CBGA synthase in hand (M23), we tested the ability to produce CBGA directly from glucose and OA using the full synthetic bioche...
ABR threshold shifts induced by cisplatin in rats pretreated with AM630 + JWH015 were 5.6 ± 1.2, 15.6 ± 2.4, and 24.3 ± 3.1 dB at 8, 16, and 32 kHz, respectively, which were similar ...
On the other hand, FAAH−/− mice (having elevated eCB levels) showed reduced allergic responses (29), further arguing for the concept that elevation of the eCB tone (e.g., by abrogati...
Therefore, the potential of CB1Rs as targets for diseases of the CNS, and also peripheral disorders, has been limited by the psychoactive side effects derived from their agonists, an...
Interestingly, we found that other antagonists of mammalian CB receptors also suppress dauer entry, while the nonselective CB receptor agonist, O-2545, not only inhibited the activit...
Psychoactive Ingredients of Cannabinoids The main psychoactive ingredient in cannabis is THC, which is a CB1 and CB2 receptors partial-agonist and the most potent cannabinoid that i...
Compound 12 was synthesized using a literature procedure and NMR and MS data matched reported data (Cheng et al., 2008). In accordance, brain uptake of [11C]MA2 (1.6% ID at 2 min pos...
In mammalian tissues, two main subtypes of cannabinoid receptors, the cannabinoid receptor 1 (CB1) and cannabinoid receptor 2 (CB2), which are G protein-coupled receptors, have been ...
Orexin Receptor Variants Genetic variants of the orexin system have been identified. Confirmation that naturally occurring orexin variants are functional, let alone pathogenic, is d...
To further verify the role of MGLL in lipid accumulation in TAMs, we constructed a transgenic mouse model with specific overexpression of MGLL (TgMGLL) in myeloid cells (Supplementar...
We show that JWH-015 inhibits tumor cell viability and induces apoptosis of breast cancer cell lines (murine) 4T1 and (human) MCF7 in vitro and attenuates primary tumor growth and me...
Neuronal CB1 activation was shown to exert neuroprotective effects, while CB2 activation on T cells has been described to have a direct immunosuppressive effect [68]. [Google Scholar...
CBG Exerted an Antioxidant Action in NSC-34 Cells Treated with Medium of LPS-Stimulated Macrophages As we said above, inflammation and oxidative stress are two correlated processes,...