Electrolyte leakage as a result of cold intensity treatments (ELDL) differed between cultivars (F = 17.108, p < 0.0001), plant age groups (F = 3.870, p < 0.05), and detached-le...
The tissues from the CTRL- and the AD-dogs were processed to obtain cryosections. AD dogs. Cannabinoid and Cannabinoid-Related Receptor Immunolabelling in Keratinocytes All the rece...
The extracts were stored at −20°C until further analysis. The enzyme prenyltransferase (PT) catalyzes the alkylation of GPP and OA to create the precursor cannabinoid, cannabigerolic...
Activation of AT1 receptors (AT1Rs) by angiotensin II (Ang II) can release endocannabinoids that, by acting at cannabinoid CB1 receptors (CB1Rs), modify the response to AT1R stimulat...
To further investigate the effects of smoked marihuana (cannabis) on these biological effects in human peripleural blood cells, we analyzed its effects on DNA methylation, CB recepto...
Given the paucity of such studies, the current work investigated normative distribution of cell type specific CB1R within two representative cortical regions using healthy postmortem...
The complex pharmacology of these compounds has made it challenging to elucidate the mechanisms through which delta-9-THC, CBD, and other phytocannabinoids mediate changes in neurotr...
Huntington’s disease (HD) is a neurodegenerative disease with a progressive decline in motor and cognitive function. The dysfunction of eCB signaling observed in HD models is not con...
Our results demonstrated that CB1 activation suppressed M2 macrophage differentiation and tumor growth by downregulating EGFR. After treated with ACEA, the expression of CB1 was incr...
The endocannabinoid system consists of endocannabinoid molecules, enzymes, and CB1R and CB2R (Gi-coupled) receptors. Herein, we describe the beneficial effect of an orally administer...
throughout the study. While statistical analyses were performed only on the 34 patients who completed the study, safety data related to adverse events and concomitant medications inc...
Of the many cannabinoids in Cannabis, only a few have been characterized by X-ray crystal analysis and they include: delta-9-tetrahydrocannabinolic acid A (THCA-A) (Skell et al. 2021...
We found that in both males and females the baseline saliva levels were lower in FAAH knockout mice (Fig. Our working hypothesis is that FAAH deletion/inhibition increases NAE levels...
While ECS was shown to regulate both cancer cell progression and bone homeostasis, it was not known whether this system also affected the interaction between cancer and bone cells du...
Impact of Cannabinoid Treatment on Sleep The impact of the cannabinoid treatment on sleep disturbances was assessed using the CSHQ. [Google Scholar] [CrossRef] [PubMed] Wang, L.; H...
The biosensor was able to detect both compounds. We constructed the luminescence reporter strain KM206 (Supplementary Table 1) by placing NanoLuc expression under the control of PFIG...
JWH-018 Study Subjective and performance data after an acute dose of JWH-018 was taken from a previous study performed by our group (31, 32). Subjective high score demonstrated a si...
The term “marijuana” refers to the parts of or the products from the cannabis plant that contain THC, while industrial hemp refers to plants that have minimal THC (National Center fo...
In analyses where the main exposure was adult SLEs, we also adjusted for SLEs in childhood, to estimate the effects for adult SLEs irrespective of having experienced child stress. Pa...
Although the potential of GPCRs as therapeutic targets is still considered to be high, there have been only a few recent approvals of drugs targeting these receptors. As would be exp...
CB1 receptor activation regulates the anti-inflammatory pathway L-PGDS/15d-PGJ2/PPARγ to promote the activation of this transporter. In conclusion, the current studies suggest that a...
Finally, Fig. 4g,h present fluorescence intensity values near 0% for both NPs and the encapsulated molecules corresponding to cell cultures incubated at 4 °C to inhibit energy-depend...
Is the optimal time spent under long-day lighting different for maximal floral biomass production vs. maximal cannabinoid concentration in inflorescences? Our inclusion criteria requ...
In any case, when all receptor binding data are taken as a whole, it is relatively clear that CBRs expressed in the cancer cells examined exhibit very distinct receptor binding and f...
; Gardner, E.; et al. Functional expression of brain neuronal CB2 cannabinoid receptors are involved in the effects of drugs of abuse and in depression. Progress in brain cannabinoid...